Reinfection with mono is possible, and possibly occurs with an increased incidence in those with prior infections.
One thing to consider would be that the monospot test may remain positive for up to 1 year. Because of this possibility, you may want to consider more specific testing for the Epstein-Barr virus. This can be done by measuring the EBV antibodies.
Treatment for mono continues to be supportive. However, if this is truly a case of relapse, or chronic mono, a referral to an infectious disease specialist can be considered.
These options can be discussed with your personal physician.
Followup with your personal physician is essential.
This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.
Kevin, M.D.
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