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463339_tn?1207536484
Hey there!  So sorry to hear things have been SO tough for you.  Well, we evaluate egg maturity even if we do not do ICSI, we just do it after the insemination process, but it is a valuable tool to aid in normal fertilization.  

I do agree that your fertilization rate is not bad but there may be more to the story that makes your RE think ICSI is a good idea.  The thing about assessing maturity with ICSI is even without immature eggs won't fertilize normally.

AZH is a good idea if doing a day 3 transfer, we always recommend it and most peope choose it.  On your last cycle, what day was your transfer of a 3 cell and 4 cell on?
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463339_tn?1207536484
Thanks so much for your post.  I think this is the biggest area of misconception we see at our office with our patients and I see it all over the board.

We do not see any difference in success rates between day 3 and day 5 transfers because the decision of what day to transfer is made with a lot of care and consideration -- let me tell you how its done where we work.

Usually, with all factors equal and considered we usually start a patient as a day 3 transfer, then if they have a failed cycle with a day 3 transfer we usually transfer them to day 5 for the next cycle.

Day 3 embryos are NOT bad -- but if we have a patient with only 2 embryos on day 3, we'd rather get them back into the uterus.  HOWEVER, if we have a patient with 6 embryos on day 3, there is no way to accurately decide what to transfer, so we will usualy wait until day 5 when a lot more development has happened so that we can pick 2 out of those 6.

I think there is a lot of hating on day 3 embryos when really we would not be transfering them if we thought they were hopeless and I do believe most clinics wouldn't do that, it is totally unethical.  So don't be discouraged and ask questions.  If they call you on day 3 and say COME TODAY ask why -- ask if your chances of success will change -- ask what the grades of the embryos are, or ask to see a picture.

If you ask, there is a good chance they will lay it all on the table for you.  But truly, our success with day 3s is NO different than with day5s!  Good luck gals!
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Avatar_f_tn
Thank you for your response. They transferred both embryos on day 3. A day 5 transfer was never even mentionned, I'm not sure if they do them at my clinic. AH wasn't offered the first time, they said they only do it if there have been previous failed attempts. Does AH help the embryos develop at all, or is it just to aid implantation?
My RE said they would do day 1 ICSI, is there much difference between day 1 and day 2?
I really appreciate you taking the time to answer so many questions for all of us! It truly is appreciated.
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Avatar_n_tn
Hi Lyn!  I am so glad that I discovered this website and you and your advice!!!  I am 42 years old.  My husband and I just completed our first IVF cycle.  After starting out with 13 follicles, we transfered 6 embryos on day 3 - this past Friday, and will take a pregnancy test on June 20th.  I was on lupron, follistim and ovidrel.  I am now taking progesterone twice a day.  A year ago I had 46 fibroids removed from my uterus.  Prior to that, I had suffered a miscarriage at 10 weeks after getting pregnant naturally at age 40 just two months into my marriage.  Right before this first IVF, we tried IUI but were unsuccessful.  My doctors thought that we should transfer a minimum of 4 embryos and possibly 1 or 2 more due to the 10% chance of success for someone my age.  We thought it was better to put more in to perhaps increase the chance.  My doctors were in accord with transferring 6 total.  If this doesn't work, we will try IVF a few more times with my eggs and if that still doesn't work, we will consider donor eggs.  My husband is 37 and has very good sperm.  I guess my question is, what do you think of the decisions we've made with the transfer, amount of embryos, the 3rd day of transfer, etc.  Also, have you seen any success with women my age - 42 or older who have had children with their own eggs via IVF?  What advice would you give me?  Thank you!!!  Sasha
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183933_tn?1290220562
Hi!

I agree! I had no idea we are able to talk to the embryologists at the lab. That was news to me! I called to ask my RE a question about my embryos, the lady who answered the phone said she was no longer there, next thing I knew the embryologist was on the phone. It was great, like an early Christmas present!!

I am moving to a day five. Out of the four fertilized embryos, they are all still around, plus the two that they were waiting on to see if they ever fertilized did! So now I have six. Out of the six embryos I was told that four were 8 cells graded 1, which at my lab is the highest grade, one of the others had 7 cells graded 1, and the last one had 7 cells graded 2. So they said they wanted to try for a five day transfer. Kind of makes me nervous! I'm really praying that I have at least two good ones on Tuesday morning. Last year I had two great looking blasts on day five so I'm hoping it will be the same this time. I'm just hoping we don't get to day five and have nothing! I will keep up a good attitude though, I was just getting excited about the day 3 transfer and now I have two more days to wait and be nervous.

Is a seven cell embryo on day 3 still a pretty positive outcome? I know ideally they really like to see eight cells. Thanks, Carisa
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183933_tn?1290220562
Hi, I have one more question-If I have six embryos that look good right now, are there any average statistics on how many I might still have on Tuesday morning? Or does it completely depend on each situation? Thanks, I hope I'm not harassing you. ;)

Carisa
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186627_tn?1257881374
Thank you so much for your imput.
It was very helpful.
I'm now in the TWW after we transfered 3 day 3 embryos.
I'm hoping to get a BFP in 10 days.
Thanks again!
Miky
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Avatar_f_tn
Thank you for responding....sorry it is taking me so long to get back with you.  I started stimming on May 30 PM - so I am have actually been stimming 10 days.....My E2 on Sunday AM was 2953.  Up from 1318 on Friday AM.  They had cut my stims to 1/2 vial of  Menapur that Friday night and Sat Night.  The AM injections was 5 units of Lupron and 25 follistim.  Not much....but it seems to have a delayed reaction when you cut back.  Now since yesterday......I am coasting....no stims..just my Lupron.  My largest follicle is 17 and maybe one or 2 16's but a whole lot in the 14 range.  I have at least 11 on one side they are counting and on the right more than 12.  Isnt that crazy...but when I went in for my intial 3day b/w I had 9&9......which suposivley is good.  So, with that FSH coming back high(11.8) and it is not due to DOR.....Do you think it is going to mean the quality of my eggs is bad?  
I dont know if I mentioned this earlier or not but my DH is a CF carrier and has no sperm when they did the analysis....so they are doing aspiration on him....or whatever necessary to locate it.  They believe there is some there - but the urologist couldnt feel were the vas deferens was connected.  All his blood work came back within normal range.  So, any  input on this....does this really decrease my odds.
I do want to tell you that your job is really cool......it has to be so rewarding!  I really do appreciate your help and thanks for giving your time to calm us crazy ladies down.
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183933_tn?1290220562
Just wanted to update you on my transfer. We transfered 2 embryos on day five. One embryo was a blast, grade 1 is the best grade at my clinic, and it was already starting to hatch. So that was kind of cool. My other embryo was a c/m, I think it was a compact morula? Does that sound right? I'm sure you are aware of what I'm trying to say. That one was a grade 2 and was running a little behind. They said that once it is in it's natural environment it may catch up to the other one. But over all it looked pretty good.

I do have yet another question for you if you don't mind. I was told today that the eggs that died right away when trying to do ICSI were acting like the eggs of a 40 yr old woman. I am 30. I have chronic EBV and they are thinking that is probably why. There were around 5 out of 13 that were behaving that way. I'm wondering if the two embryos that did implant will have a chance at surviving even though the others were not behaving correctly. I'm just hoping that not all of my eggs are doomed just because around half were not right. I hope you are following me, I know it's confusing the way I said it. Could I assume that because they made it as far as they did that they are probably ok? I'm panicking a little. Thank you!! Carisa
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414225_tn?1247459100
Welcome, welcome, welcome!!  I have nothing but respect for what you do, Bless you!!  What's your professional opinion regarding activity and how much and how many days post transfer, and working out.  This is my 2nd IVF with ICSI and donor eggs....we want this pregnancy so much.  Any advice is appreciated.  I'm 2 days post transfer, thanks in advance.
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HI..  Thank you for being here to give us all some much needed advice!!  I was hoping you could give me your opinion on my past IVF cycles..  

I'm 34 and I have been through 3 cycles so far.  The first one resulted in 2 negatives (fresh and frozen) - the last 2 were both chemical pregnancies.  We are now in the process of trying to determine why the embryos aren't staying attached.  Here is a little background..  each cycle, I have a fairly good response to the stims.  I have had 24, 16, 21 eggs retreived respectively.  The first cycle, 12 fertilized, 6 were left on day 3, we transferred 3 excellent embies and froze 3 - both ended in negatives.  The 2nd cycle, only 6 fertilized, we transferred 3 excellent embies on day 3, and left the other 3 in culture until day 5 - which they didn't make it.  The 3rd cycle, 9 eggs fertilized.  On day 3, I had 9 really good embies - so they decided we would go to day 5.  On day 5, I had 2 excellent (but early) blasts transferred.  No others were left to be frozen.  So, what confuses me is that, especially in my last cycle, my eggs and embryos looked so much better.  After my retrieval, they came in and told me that my eggs looked great.  And then, each day when I would get the report on my embryos, they would tell me how great they were looking.  And for each transfer, even though we only ended up with a few left at that point, they have always been rated as excellent.  But, at this point, my RE is telling me that he thinks my egg quality isn't good and that I should start thinking about using an egg donor.  Based on your past experience and the cases you've seen in your lab, what would you think?  Was it a sign that there was a problem with my embryos when they were labeled as 'early blastocysts' or is it common to see these on day5?  Do you think egg donor is the route I should consider at this point?  It's a hard pill for me to swallow that, after 60 eggs, not 1 has stuck.. but I just am having a hard time accepting that this may never work for me.
One other note, my RE is also pushing me to do PGD if we decide to try another cycle with my eggs.  I realize that there is great benefit in this - but I can't justify paying $6000 if we only have 2 or 3 embryos left to be tested.. any thoughts about that.
I know I have asked a lot of questions.. but I can't tell you how much I appreciate the time that you are willing to give to all of us wannabe mommies..
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Avatar_f_tn
Update:   Okay so the Re took me 2 days no stims just lupron and on the next u/s bw day my E2 dropped from 3600 to 1500..then he gave me directions to stim one full day and come back...today i went in (which should be my last appt prior to triggering) and my follies one at 18, 3-17, and quite a few in the 15/16 range.  So he wants me to push one more day....but I am still waiting on my E2 to come in.......he says I could have shot back up and he might have to cancel me if that happens.  So, I am waiting.....any opinion.  
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463339_tn?1207536484
We alwyas do assisted hatching because it does increase implantation rates -- but it does not aid in embryo development.

Does your doc consider day 1 day of retrieval?  We consider that day 0 so I was a little confused.  If so, we do all day "one" ICSI (day of retrieval) and only do day 2 if there were immature eggs from the day before whch matured and only if the person doesn't have much to work with.

Good luck!
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507875_tn?1322621651
Is it safe to have a colonic while trying to conceive?
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463339_tn?1207536484
I am so happy to hear from you!!!  Well 6 embryos definitely is aggressive, but congrats to you on having many pretty embryo babies for transfer.  It is true that the success rate is lower, and since about 80% of eggs are chromosomally abnormal once you are over 40 its not totally unreasonable to transfer so many.  However, we usually cut it off at 4, that is also considering most people your age wouldn't have 6 embies, we might just do it too!!!

If you tell me what clinic you are using I can get you there specific success rate from 2006 -- we have the book of ART success rates.   Our last year, we have about 25 females over 42 and 4 had a life birth (that is considering a number of them miscarried.)

I wish you the best of luck and if you do decide to do donor egg, just remember that you get all the joys, and not so joys of being preggers with a super high success rate (we are 70-80% with donor egg).  GOOD LUCK!
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216278_tn?1308864682
Hi!  I know that you are an embryologist, but do you have any knowledge about hormonal levels and what are some ideals?  I had my DHEA tested and it came in at 95 - I was wondering if that is an ideal number or low or high???

Thanks for being so supportive to everyone on this site! You are a valuable resource!!!
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463339_tn?1207536484
CONGRATS on having 2 beautiful embryos for transfer.  DO NOT get all in a tizzy.  First of all -- we have patients with half of their eggs are **** and they end up with BEAUTIFUL embryos!!!  That is mostly because each egg is more or less independent of the others because they are each coming from a different follicle so don't get down on the embryos -- dont hate on them!!

Your breakdown looked good tho because we usually see about 50% make it from d3 to day 5 so that is ALL good!  Keep me posted!!!
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463339_tn?1207536484
Thanks so much for your kind email!! It really meant a lot to me!  That is a good number of eggs you are working with :c)  I would not be too worried about egg quality, I would wait and see how the cycle goes before you get worked into a tizzy.

And the good thing about ICSI is that we don't need a lot of sperm, just a few motile guys ;c)  We do tend to see a lower fertilization rate with TESA sperm because we don't necessarily have enough motile to inject all the eggs and when you inject non-motile there is no guarantee that the sperm is alive and dead sperm will not fertilize.

Try and be optimistic, it seems like you have a lot of positive stuff going for you!  GL!!!
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463339_tn?1207536484
We don't usually recommend a time for not doing physical exercise because there is no data to suggest what is good or bad.  We always say to do what you feel comfortable with because you don't want to ever blame yourself if you lose.  GOOD LUCK!
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463339_tn?1207536484
Oh my goodness!  How very terribly frustrated you must be!  It sounds like you have been through a TON of stuff, and it just doesn't make any sense, I can see where you are feeling torn to pieces!

I think there is definitely something going on with your eggs because that is not a very normal response.  Really early blasts on day 5 isn't a terrible thing, we sometimes get nervous if they haven't blastulated at all by day 5 but even then if they are beautiful, we will usually still transfer them.

PGD is definitely an option but like you said it is so expensive.  We do PGD on day 3 and then transfer on day 5 and we will usually call the patient and say "Ok, we only have 3, do you still want to do PGD?" So that they aren't out 6 grand on three embryos.  Because even insurance in IL doesn't pay for PGD.

And please don't ever WORRY about asking a lot of questions -- I absolutely LOVE what I do and am so happy to share whatever I can.  I see where it is hard to give up on your own eggs, so its a choice you have to make of how much you are going to let yourself go through before you go to donor egg, or adoption.

If there is anything else I can do to help you, please please please let me know!  I will be thinking of you and all the other wanna be and really should be mommies!! Take Care!
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463339_tn?1207536484
Really I know a lot about hormones but nothing about DHEA unfortunately.  I would look online or ask your RE, thats what they are there for!  GOOD LUCK!!!
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Avatar_n_tn
Hi,

I am 30 yrs old with PCOS and stage 1 endo.

I underwent 4 IUI with letrozole+FSH injections and first IVF recently.

IVF results:13 eggs retrieved,only 4 fertilized.
Embryo quality:4 is the best at my clinic.(at 72hrs)
#1 ;Grade 2,  4 cell
#2 and #3:Grade -2  ,6 celled
#4:  Grade -2  ,5 celled.

All four were transferred and I am in 2 WW period.

I am very disappointed about the whole cycle.Can you please tell me why you think :
1)The fertillisation was so low?
2)The embru quality was not good.
3)From your experience what is my chance to conceive.

I live in Champaign,IL south of chicago.Can you tell me as which place is best for me to go for the next cycle if this fails.I am planning on Advanced Fertility of Chicago,do you have any opinions about it.

Thanks a ton.

Richa.
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183933_tn?1290220562
Thanks for the breakdown on the egg situation!! I over think everything, it's awful! I'm so glad that I ended up having a few eggs that were good, I feel so lucky. I got a call from the embryologist at my clinic, Pacific Fertility Center in San Francisco, and he said that my blast was beautiful and it's one you would find in a textbook!! I was very pleased to hear.

My final and last question (hopefully) is if it is necessarily a bad thing that my other embryo was a compact morula at day five? They gave it a grade 2, grade 1 being the best. Is it still possible that once it is back in it's natural environment it could catch up? I've never heard of a day 5 c/m.

OK OK, I'm done asking questions. The next time you hear from me will be after my pregnancy test next week. Promise! Carisa
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414225_tn?1247459100
Thanks for your input...you're a very dedicated practioner, kudos, babynr.
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463339_tn?1207536484
Hello!  I am a formr resident of Champaign so I quite familiar with the area.  I don't really feel like I can recommend one clinic over another because I work in IL and honestly am probably very biased -- but I can give you their success rates ;c)

For Under 35:
Number of cycles 174    
Percentage of cycles resulting in pregnancies  51.1  
Percentage of cycles resulting in live births  44.8    
Percentage of retrievals resulting in live births 47.0    
Percentage of transfers resulting in live births 48.8  
Percentage of transfers resulting in singleton live births 27.5
Percentage of cancellations  4.6  
Average number of embryos transferred 2.0  
Percentage of pregnancies with twins   38.2  

So all in all -- those are great numbers and I would feel very comfortable there.  The most important thing is finding a doc you feel comfortable with.

It is hard to know why the fert rate was so low, but in combination with the embryo quality issue it could be an egg issue, but onc again those could both be caused by poor sperm quality too.

I would not give up SO easily because you are so young, I think you still have great chances of success.  We can learn a lot from the first cycle which helps in subsequent cycles so try not to get too down on yourself!  Good luck!!!

Richa.
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463339_tn?1207536484
Yes, a day 5 compacting morula is not a terrible thing because it is the pre-cursor to an early blast.  If we have two embryos, one that is blastulated and one that is a cm, we will transfer both.  If none of the embryos had made it to blast, we might cancel unless the cm was really nice.

Its ok to overthink, we are women and its our god given reproductive right to have children, and when something stands in the way of that, we are going to over think it.  Cause that is what we do!!  No worries -- and never too many questions!
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Avatar_n_tn
Thank you very much Lyn.I really appreciate your input.Looking at the numbers I feel very comfortable approaching Advanced Fertility Center Of Chicago.

What do you think my chance to conceive this cycle?All four were transferred and I am in 2 WW period.

IVF results:13 eggs retrieved,only 4 fertilized.
Embryo quality:4 is the best at my clinic.(at 72hrs)
#1 ;Grade 2,  4 cell
#2 and #3:Grade -2 (Minus 2) ,6 celled
#4:  Grade -2(Minus 2)  ,5 celled.


I am terribly stressed out regd if I will conceive this cycle.Please let me know.

Thanks,
Richa.
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324913_tn?1302873117
Hi there... I was wondering if you can answer something for me.  I'm currently stimming for my 4th IVF.  The tries have been back to back aside form 1 month of b/c inbetween.  Only this last try there was no month of b/c.  
That said, AF showed quite late this time... by a couple of weeks.  And I had no cyst or anything like that.
However, she showed and I did my b/w and u/s and all was fine and I started stimming with 210 IU of Puregon (1st time we use Puregon) on day 2 of AF.
Today is day 10 of Puregon and I feel like AF is about to show!!
I have some cm and my lower back is quite sore and I've had a couple of other symptoms.  I can explain all the symptoms away with other things except for the cm.
Is it possible that my body is about to flush away all my precious follicles??
Or is it normal to experience cm and I just haven't previously noticed it or it doesn't happen so much with other stims??
I would really appreciate any advice / opinion.
Thanks
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276562_tn?1220885624
Hi-
It is so nice to have am embryologist to ask questions about our cycles with.  I just had my first transfer on Thursday.  I am 28 almost 29 years old with unexplained infertility.  We did 4 IUI's with one resulting in a chemical pregnancy.  So we had 20 retrieved and 15 fertilized.  We transferred our 2 best which were 5AA and 3AA (5 being the best at my doctor's) on a 5 day transfer.  How does this sound to you?  Promising?  Your input is greatly appreciated.  
Thanks,
Lisa
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Avatar_f_tn
Hello their

I am feeling devatsted at present and cannot sleep. We did our first IVF cycle. i am 32 and we have  a male factor issue. At retreival that got 9 eggs and then called to say 8 of them were immature. The doctor then said that a couple fo them were very strange shapes which he wasnt sure why but felt it was some concern. That did ICSI on the one egg that was apparently perfect and a great size and it failed.

Having always been really firm about having chidren, being a very healthy natural person and never expecting that dream couldnt come true. i am suddenly faced with the fact that it wont. With this kind of cycle suddenly our chances seem low - the doctor said he didnt think i responded well to the drugs and maybe it would be different naturally.

I am absolutely devasted and can nly think of having a sperm donor so i can do the turkey baster method which is more natural.

Have you seen anything like this and what are your thoughts its 4 in the morning and i am trying to work out how to let go of all this stuff.

many thnkas
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Avatar_f_tn
Hello....well they managed to keep my E2 down enough to do ER(yesterday at 8am)......I had 15 eggs retrieved 14 were mature and 9 fertilized.  I havent gotten any other info yet....I guess that is really all they can tell you so far.  Can they give you a grade yet...or do they have to wait 48 hrs...or so?  I am hoping for the best of course!!!!  

I am 37 yo with the FSH of 11.8....which I was told would lower my chances.....My RE did put me on the DHEA and I took it for 4  months.....I dont know if this played a roll in my cycle but I feel like it may have helped in the quality of my egg.  Does your group use it?
Thank you for any insight!!!!!!!
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Thanks so much for responding!  I really appreciate it!  I am having my IVF treatments via the Cleveland Clinic.  Thanks for offering to get the specific success rates for me.  Again, I am 42 years old and had 6 embryos transferred a week ago.  I used my own eggs.  My husband and I are thinking that we will try IVF for a few tries if this one is unsuccessful before going to donor eggs.  How many tries would you suggest knowing that at my age I did have 6 that were transfered?  We started out with 13 retrieved and in the end 6 were transfered.  Also, would my sister who is about to turn 40 in October be a possible donor for me with her eggs in the near future if we choose to go that route or would you recommed someone a lot younger?  I will know the success of this transfer on June 23rd.  Thanks!  
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183933_tn?1290220562
Hi again!

Ok, I have another question for you. I'm still thinking about my compact morula that was transferred along with the blast on day five. You said you may get a little nervous if you don't see the morulas starting to blastulate on day five. How do I know if my compact morula was starting to blastulate? I know I sound like I'm obsessing, and yes......I am! Thanks again!

Carisa
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183933_tn?1290220562
I forgot to add that they checked them around 9am in the morning. Is it possible that it started to blastulate a little later on in the day? Carisa
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Avatar_f_tn
An Actual Question about embryo's.......After fertilization if they are going to be identical twims at what point to the egg begins to divide and at what point is it too late and it will for surely only be one?  I had 2 transfered Tuesday...8 cells...one a grade 5, and one a 4+.  I am excited!  Oh I also had one that was always 2 cells ahead of the rest and they wanted to watch it for a 5 day freeze - it was a grade 5 (the best in our clinic) so what would be wrong with it?
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Hi Their

I now have official information about my eggs which didnt turn into an embryo. Maybe yu have seen this before. Three of my eggs were scrunched up and dehydrated. Have you ever seen this before and if so please tell me what it may mean. The doctor has no idea and so its quite hard for me, 5 of the eggs were immature (follicel sizes over 18mm) amd one egg was mature which dint fertilise.
Any info would be a godsend
thankyou!!!!!!!
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463339_tn?1207536484
Here is a big mass answer to all of you -- sorry but I have been kept SO busy with IVF haven't had much time to get on here!

landdwantababy -- I think that sounds very promising! Keep me posted!
malvern

malvern -- So sorry to hear about your bad cycle.  Have they thought about doing any more testing to see if there are some other issues they can help resolve for a future cycle?  If you think donor sperm is going to help the issue I would give it a try!

Well dehydrated eggs, not really -- unfortunately those are terms we really do not use.  As far as them being immature, that is often caused by the stimulation cycle, but can be due to overall ovarian health.  I do hope they can give you some information which will help them move forward with treatment!

babycrzy1 -- sounds like great news all around!  There are cases of identicle twins with IVF because the embryo can split after the transfer, however, most IVF twins are just from two embryos.  And it does take time before they can grade.  The day of fertilization they can only say if it fertilized or not -- nothing more really, there is just nothing much to see until the embryo starts dividing!  Good luck and baby dust!!!

sashalake --  We usually recommend a cycle for 2 before moving to donor and if the cycle goes "well" as many as three or 4 times before moving on.  40 is a little old for a donor simply because a lot of eggs in a patient over 40 are going to be abnormal.  We usually see donors in their 20s and 30s.  I do hope for the best for you -- EMBRYO GLUE!!!

Carisa-  That is definitely possible.  We definitely like to see some expansion by the afternoon.  When embryos set up their "timetable" for division, it can vary by a number of hours -- so sometimes your embryos are just not at the same stage at the same time.  Doesn't mean one is better or worse!  GL!!






  








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183933_tn?1290220562
Thanks for responding to all of my questions! It has been very helpful. Just wanted to let you know that I did get a BFP and it was 9 days post 5 day transfer. The number was 177!

Carisa
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495055_tn?1259704550
Hi!  
Thank you so much for being such an amazing resource.  DH has a male factor diagnosis (low motilaty - under 10% - and count - under 20 million).  He is on arimedex (sp?) and will be starting clomid.  

We had a failed IUI cycle.  The cleaning brought DH's motilaty down to basically 0%.  The Dr. has reccomended  IVF with ICSI.  The nurse indicated that the motilaty is not an issue.  Can you please explain this process a bit?

Thank you in advance for your insight.  
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531467_tn?1228418963
Hello.

I'm not sure if you ever answered this.  I tried to read the entire thread, but it is bit overwhelming.

I'm 38.  I've had 3 failed IUI's and 2 failed IVFs.  During both of my IVFs, the embryos (3) were all high quality and my lining looked good.  They were all transferred day 3 with 8 cell, 8 cell, and 6 cell.  Everything was optimal and best as it could be.  So, what could be the reason(s) that the embryos will not implant?  

I have an unexplained infertility.. except old age :( .  I'm debating whether to try one more time or just let go.

Thank you soo much in advance.

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Avatar_n_tn
Thank you very much Lyn.I really appreciate your input.Looking at the numbers I feel very comfortable approaching Advanced Fertility Center Of Chicago.

What do you think my chance to conceive this cycle?All four were transferred and I am in 2 WW period.

IVF results:13 eggs retrieved,only 4 fertilized.
EmbryoCea quality:4 is the best at my clinic.(at 72hrs)
#1 ;Grade 2,  4 cell
#2 and #3:Grade -2 (Minus 2) ,6 celled
#4:  Grade -2(Minus 2)  ,5 celled.


I am terribly stressed out regd if I will conceive this cycle.Please let me know.

Thanks,
Richa.

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Avatar_f_tn
Okay...this 2 ww will kill me yet....they called today day 6 to let me know that all 5 of my embryo's didnt make it to blast...she said that they got real close bt didnt make it.  SO now I worry that the ones they put in arent gonna make it.....they tried to assure me that they are in their natural enviroment and it is total diffrent than being in the culture.  I hope they continue to grow.....they were both great quality.  Any reassurance that I should compare the ones on the inside to the ones that were on the outside.
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It's Sasha here.  Unfortunatley, none of my 6 eggs implanted.  Thanks for the information by the way.  We will continue with IVF for a few more cycles hopefully.  Can you please still get the success rates for 42 year olds at Cleveland Clinic in Cleveland, Ohio?  Thanks!  Also, I believe my cycle should come on in a week or two.  What is your opinion on ttc on my own while waiting for the next IVF cycle?  Should I try to figure out when I'm ovulating and go from there?

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Avatar_f_tn
Ok so I am 7dp3dt - getting a faint positive First Response Early Response test.2 times.....I triggered 2500 Ovidrel 12 days ago........I took a cheap walmart brand test 4 days ago and it was negative.....so hopefully most of the trigger was out of my system then.....What is your take? Can I be happy yet?
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294043_tn?1329271015
I have a question about embryo quality.  If a person has low quality embryos (only 5-6 cell on day 3 and all fragmented) does that mean a higher chance of chromosomal abnormalities if the embryos implants and develops into a fetus?
Thanks!
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Hi i have a question i hope you dont think it's silly im 38 and i did my last ivf cycle in nov/07 wich failed.The night before my transfer i walked to the pharmacy to pick up my prenatal pills  and as soon as i stepped outside it started pouring rain  i was soaking wet i lived close by so i ran home about two blocks.In the morning i felt a bit of a chill alsmot like flu symptoms that came and went.Do you think that is the reason why my ivf failed i had my transfer on day 5?....When i spoke to my doctor she said it could of been due to stress.
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It is nice to have you here.  I am a 41 year old female who is on her last day of her 2ww after my first FET.  I transferred 3 embryos and I am crossing my fingers for a BFP this time.  Remarkably enough when I did my retrieval there was 19 eggs of which 11 survived and 7 made it to the 5 days stage.  Since I was in a study they transferred only 2 on my fresh cycle but I got a BFN. My RE was surprised because the embryologist told my husband and I that one of the two transferred was a textbook perfect embryo and that has never been seen in a woman my age.  I have lots of hope that this time I will get the BFP I am so hoping for although I feel absolutely nothing except a slight nausea most of the day today.
Well thanks for listening all and have an awesome day.
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Avatar_f_tn
hi i would just like to say god bless you to give of yourself much needed help this is such a selfless thing of you to do all i can say is you are an amazing human being i give me faith that the world is a better place because of people like you thank you
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Avatar_f_tn
I just joined this website after coming across this string of useful information.  Are you still actively responding?  If so, I will respond with my history with IVF as I have some questions.

Thanks so much for the already posted useful information.
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Hi my name is Christine and I just had my second ivf day 5  blastocysts transfer. They put 3 excellent quality blastocyts in on  9/15 and today is the 9/19. I'm very nervous since my last ivf cycle failed. I know this must sound strange but I was wondering if the embryos didn't implant by now would I be able to see them by the naked eye when I got to the bathroom? I'm so scared every time I pee there just gonna fall right out. Please let me know.
Thanks,
Christine
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