I’m 31 years old and my husband is 32 we are married for 5years we seeked medical advice 4 years ago my husband did semen analysis and i did hormonal assay and HSG and were normal i had clomid (clomiphene citrate) for many cycles with no result i then had IUI twice while having fostimone (urofollitropin FSH) and chriomone (HCG) amp. and fail then i did antisperm antibodies & IgG & IgM aganist toxoplasmosis
and were –ve, i also did thyroid function and were normal then i did ICSI twice, during the cycle i had the following treatment: decapeptyle (triptorelin), cycloprogynova (only white pills estradiol valerate), urbazon (methyl prednisoline), heparin, asprine ,merional (HMG) & chriomone (HCG) 36 hours before ova pickup .. 12 ova were aspirated and they gave 6 embryos
then i transfere 3 in the 5th day (they were laser assisted hatched); i had prontogest (progesterone) amp(100 mg). & supp (200mg). & duphastone(progesterone 20 mg),folic
acid , urbazon(methyl prednisoline), asprin and vit.E during the luteal phase and i was having 15 mm endometerial .then i had FET the next cycle ( they were the last 3 embryos
)
I did some labs (anticardiolipin, lupus anticoagulant , antiDNA ,protein c & s ,antithrombin III) they are normal but I have ANA 1.78 ( the normal level of the lab is 1.5)
Also I had homocyctine level & had folic
acid & vit. B and the level become 3.8…
I had hysteroscopy and laparoscope one year & they showed mild degree of endometriosis with left tube showing no motility and arcute uterus which has been corrected.
Then i had genetic test:
factor xiii v34l heterogeneous mutation
beta fibrinogen 455 G>A heterogeneous mutation
MTHFR C677T heterogeneous mutation
Last month i did anther hysteroscopy and it was normal then i start anther cycle of ivf ( in another fertility center) where i had decapeptyle (triptorelin) from day 21 of the cycle the menogone (HMG) 225 iu per day for 12 days & chriomone (HCG) 36 hours before ova pickup ..also i had steroid 5mg perday and asprin 75mg per day ... 13 ova were picked 8 were fertilized but only 5 were of good quality where i had 3 embryos transferred and 2 were frozen . after the ova pickup i start the lutual phase with progesterone 800 mg vaginal supp and 100 mg as amps aslo i had estradiol valerate steroid, asprin, anti coagulant ( enoxaparine 40) and myometrial relaxant (ritodrine). i don't know what to do next shall i my FET that remain from the last cycle.. is there more investigations i should do before trying again.
Is all of this with the same dr? If so maybe seek a second opinion sometimes it helps with a fresh set of eyes on the problem. Have they checked your utetinr lining? Day 3 fsh? Amh? Day 21 progesterone levels? Sometimes these simple tests can tell a lot. Good luck.