I am not sure femara is better than clomid, but in theory there are a couple of good reasons for femara in your case. First, there are case reports of endometriosis being treated successfully by aromatase inhibitors, which is the class of drug femara is from. Second, femara results in a thicker, better looking endometrium, than clomid. On the other hand, femara is more likely to result in one egg being released, rather than multiple. I don't know of any info regarding clomid making endometriosis coming back more quickly. Why have you been prescribed femara? Are your periods irregular without a medicine that helps you to ovulate? Does your MD think it may help keep the endometriosis at bay?