Fertility / Infertility Expert Forum
Homozygous MTHFR a1298c and fertility issues
About This Forum:

Questions in the Fertility/Infertility forum are answered by medical professionals. Topics covered include fertility or infertility issues, egg quality, fertility drugs and side effects, fertility tests, genetic testing, in-vitro fertilization (IVF), pregnancy reduction post IVF, ovulation, relationship issues, risk factors, sperm count/quality, and surgery.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
This expert forum is not accepting new questions. Please post your question in one of our medical support communities.
Blank Blank

Homozygous MTHFR a1298c and fertility issues

My first pregnancy (14 years ago) resulted in a pre-term birth at 28 weeks and I have had 2 miscarriages since.  My husband and I have been trying to conceive for 14 months, to no avail.  I recently learned that I have a gene mutation (MTHFR a1298c is homozygous).  I'd like to know what impact that may have on my ability to conceive and carry to term?  I'm also curious as to how it can affect my overall health.  My current doctor has relocated and I'm in the process of finding a new one.  In light of this new info, I'm curious if I should seek a specialist as well, I'm just not sure what kind of specialist would deal with this particular condition.  Any help is appreciated!
603463_tn?1220630455
Hi!
If you were my patient, I would advise you that I found this post on our site from 2009. A reproductive endocrinologist would be the type of specialist who could assist you with pregnancy issues.  A general internist could help you if you do have abnormal homocysteine levels.  (see below)
the post is located at: http://www.medhelp.org/posts/Genetic-Disorders/What-can-you-tell-me-about-being-homozygous-for-the-A1298C--without-the-C677T-mutation/show/1054665

"The A1298C gene variant is found in the MTHFR gene. This gene produces an enzyme that is important in the metabolism of homocysteine, an amino acid.

We all have two copies of the MTHFR gene, one from each parent. People with two copies of the A1289C gene variant are referred to as homozygous. Having two variants/mutations, such as A1298C, can cause elevated homocysteine levels.

MTHFR deficiency, in the presence of elevated homocysteine levels, has been associated with a variety of health issues including an increased risk for venous thromboembolism (the formation of a blood clot in a vein), early onset cardiovascular disease, and adverse pregnancy outcome including fetal growth restriction, preeclampsia, miscarriage and placental abruption. However, these risks may not be increased in the presence of normal homocysteine levels. A blood test can be performed that measures plasma homocysteine levels.

We recommend that you continue to follow-up with your physician. We may also benefit from meeting with a genetic counselor who can review your personal and family history as well as discuss the genetics and inheritance of MTHFR deficiency. You can find a genetic counselor at the National Society of Genetic Counselors website or through companies like mine, AccessDNA. We wish you the best."

Hope this helps!
Dr B
Blank
Continue discussion Blank
This Forum's Experts
603463_tn?1220630455
Elaine Brown, MDBlank
Elaine Brown, MD - BLOG
Billings, MT
MedHelp Health Answers
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
RSS Expert Activity
242532_tn?1269553979
Blank
Emotional Eating Control: How to St...
Aug 28 by Roger Gould, M.D.Blank
233488_tn?1310696703
Blank
New Cannabis Article from NORTH Mag...
Jul 20 by John C Hagan III, MD, FACS, FAAOBlank
242532_tn?1269553979
Blank
3 Reasons Why You are Still Binge E...
Jul 14 by Roger Gould, M.D.Blank