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I am using estradiol as well.. My RE told me that is to thicken uterus lining. After using clomid from day 3 to 7, ultrasound on day 9 showed uterus lining to be 5.6mm for me. So they ordered estradiol 2mg twice a day. I am on it. and also using prometrium from 3 days after the trigger shot. hoping that it helps.