My doctors are considering a diagnosis of fibromyalgia, contingent upon the results of a recent biopsy to determine if Sjogren's is a factor. Can fibromyalgia be the cause of my symptoms that cycle (recurring fevers, rash, fatigue, pain, blurry vision, and numbness in hands and feet)? I've heard of it being a factor in regard to fatigue and pain, but am unsure about vision, rash, numbness, and especially fevers.
Also, I have been diagnosed with MGUS and genetic testing showed a variant in the MEFV gene. Is there any correlation between those diagnoses and fibromyalgia? I'm curious if one could be causing or exacerbating the other.
Get Lyme testing done through IGENEX. Do NOT use Labcorp/Quest. Those 2 labs have outdated and inferior criteria for proper Borrelia and co-infections now know to be infecting deer ticks and humans. Lymes doctors are finding this sexuallly transmittable. do some research.
No, it was not. Infectious Mycoplasma bacteria can cause Autoimmune issues.ie: symptoms of Lupus, fibro, als, hashimotos, Sjorgens, MS and others. Check out www.immed.org under Autoimmune Illnesses. There is information of Intracellular chronic bacterial and fungal infections causing Autoimmune disease like symptoms.
Then if you have done research on the IGENEX tests, you also know then that because the bacteria hides from your immune system, it IS possible for it to be neg, Theoreticaly. I would suggest posting in the EXPERT AUTOIMMUNE section where Dr Garth Nicolson is available. He has written over 300 peer reviewed and accepted papers, 3 world nenown citation papers and sits on numerous journals. I would consult him first before basing a judgement on another DR
That does lead me to wonder since certain test results, when repeated, have come back with conflicting results and some have provided proven false negatives. My understanding of mycoplasma infections is that there are almost always respiratory symptoms accompanied by the other typical symptoms of pain, fever and fatigue. I haven't experienced any respiratory issues; however, CT scans have noted a thickening in the wall of one of the lungs, yet no known cause or symptoms as a result.
They say there's no thing such as coincidence. Synchronicity
I came across the following report recently: (google the whole title. It's the first result)
"Comparison of Familial Mediterranean Fever/Fibromyalgia/Chronic Fatigue as well as diagnostic criteria and misdiagnoses given for FMF"
I do not know whether it would be helpful or not, but I found it very well presented.
MEFV is the same as FMF?
For any possible connection with MGUS, perhaps look into studies of the world's top MGUS and Multiple Myeloma expert, Dr. Robert Kyle from the Mayo Clinic.
( A very good friend of mine, recently diagnosed with Myeloma, has been diagnosed with FMS many years ago-Tender Point Test ) Who knows?
Hope you find some answers and most importantly some solutions.
Mayo Clinic is actually handling my case, and the hematologist assigned to me is top-notch as you said. They've ruled out myeloma, thank goodness, and think that something auto-immune is merely triggering the elevated monoclonal protein. However, the MGUS could also be causing many of my symptoms so it's a game of what came first, the chicken or the egg, the MGUS or the possible fibromyalgia.
They considered a diagnosis of Familial Mediterranean Fever, but because the genetic variant was recessive and my family background doesn't fit the profile, they felt it to be unlikely. They tried a course of colchicine which only knocked the fevers down, but did nothing for the rest of the symptoms which leads them to believe that this is not FMF.
I've seen some research that links the MEFV variant to fibromyalgia, but it's so frustrating to tell what research is legit since there are so many contradicting findings out there. I can see why fibromyalgia tends to get over-looked and not taken seriously by some given the lack of definitive findings.
I hope all goes well with your friend, especially given the recent diagnosis of myeloma.
Dr Nicholson states that nearly all, 99%, of Fibro and CFS is from Mycoplasma bacteria. Namely Mycoplasma Fermentans-Incognitus. The testing requires looking for a sequence of DNA in a blood smear sample(s). I would be woth your while to investigate this further.
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