I took topomax for severe chronic migraines and had a lot of trouble with it. I would get confused, I couldn't carry out the simplest of tasks like calculating if I received enough change back at mcdonalds one night. I sent my boss at the time to atlanta and didn't book him a return ticket, I would be driving somewhere and forget where I was going. I didn't sleep, metallic taste in my mouth. My aunt on the contrary takes it and it has been life saving in regards to her headaches. So I think everybody is different.
I agree with the above poster have you taken muscle relaxers or any RLS type medications? Wishing you luck.
Maybe Flexeril?
I took Topamax for years for my migraine, worked great. If you twitch is due to seizure activity, maybe Topamax would help.
Good luck!