I have read conflicting information on whether GERD can actually cause shortness of breath. I'm 38, male, smoker, placed on Prilosec last week by my GP. Since I began taking the Prilosec (20mgs per day), I've had several episodes of disturbing shortness of breath...they happen at different times of the day and aren't associated with any physical exertion. I wasn't actually choking or gasping for air, but my chest definitely tightened and every breath felt very shallow. EKG, ECG, and stress test in April 2008 were negative for cardiac issues. I'm wondering if GERD could be causing this or even if Prilosec might be to blame.