ELEVATED SGOT/SGPT

  : : My daughter, 18, down syndrome,  had blood work done in 9/98 which revealed a diagnosis of hypothyroid, (6.95) and elevated SGPT (310) and SGOT (210).  Prior to this blood work, she had a bronchitis type cough that had been present since 8/15/98.  She was treated with z-pack(an antibiotic she had never taken before), tussalon perle cough capsules and dihistine DH.  This medication would have been prior to blood work.  She was treated with chemotherapy for AML from 1981-84 (no radiation) and also had three open heard surgeries for VSD repair (many blood transfusions prior to blood being screened).  From 1984 until present she has had no unusual medical concerns.  All other liver functions, including TSH are normal, and she has tested negative for Hepatis A, B, and C, also for cat scratch disease. In blood work from 1/9/99 SGPT was 240 and SGOT was 170.  Her oncologist completed a CT scan of her chest and abdomen which was unremarkable.  It is being recommended that she see a gastroenterologist and have a liver biopsy. I hate to have her subjected to an invasive procedure. Is the drop in her SGOT and SGPT not significant enough to warrant waiting for a couple more months to see if there is another drop.  The cough that I mentioned that she had 8/15/98 lasted through the end of November and did not respond to an antibiotic.  Is it possible that the virus that cased that infection could have affected her liver?  What about the medications she was on?  Is there any connection between her hypothyroid, which we found out later was slightly elevated (4.58) in other doctor records as far back as 1993 could have any connection with the elevation of liver enzymes? Is it unusal to have only the SGPT and SGOT elevated?  I realize that this is an extensive list of questions, but I would like to start gathering information prior to our appointment with a GE in Pittsburgh.  Thank you for your time!  
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  : dear Linda,
  : Your duagter has had multiple medical problems and therefore, there are many potential explanations for her elevated liver tests.  An important point is that we can not conclude whether there is any improvement in liver tests by variations among elevated liver tests. There is a poor correlation between the extent of liver damage and the magnitude of the test elevation.  A second important consideration is that gastroenterologists usually wate six months before biopsing for elevated liver tests.  Acute causes for liver test abnormalities resolve after 6 months.  Although a biopsy is the most efficient approach to determine the cause and the severity of the liver disease, one can get indirect information regarding cause from doing additional blood and urine tests e.g. auoimmune markers, copper levels (looking for Wilson's Disease etc).
  : This information is presented for educational purposes only.  Ak specific questions to your personal physician.
  : HFHSM.D.-rf
  : *keywords: elevated liver tests
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[HFHSM.D.-rf]

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Dear Linda H,
If your daugter has marked thyroid insufficiency she may have fatty liver which could cause elevated liver tests.  Also possible is autoimmune thyroiditis and concurrent liver disease.  
This informationis presented for educational purposes. Ask specific questions to your personal physician.
HFHSM.D.-rf
*keywords: thyroid isease, live rtests
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