Gilbert's and mild splenomegaly

I was dx w/Gilbert's 12 yrs ago after an attack of cholecystitis, pancreatitis and an inflammed liver.  I had an ERCP done and it was decided to remove my gallbladder.  After my release from the hospital, my blood work began to show elevated indirect and total bilirubin counts.  This was the basis for the Gilbert's diagnosis.  Now, on routine CT scans or ultrasounds of the abdomen, there have been findings of mild splenomegaly.  Is there any relationship between the two conditions.  There is a family history of porphyria, also.  In some research, I have read that there might be link between Gilbert's and some forms of porphyria.  Should I be concerned?  I am currently undergoing aggressive chemotherapy for an aggressive form of breat cancer.  The findings of splenomegaly came before and after the dx of cancer.  Is there any correllation there?  I find myself wanting more and more answers as my treatment progresses, so please forgive the length of this "question".

[Kevin Pho, MD]

I am not aware of a strong connection between Gilbert's and splenomegaly.  

There are a variety of other causes for an enlarged spleen, including the cancer itself and other blood disorders.

Looking at a peripheral blood smear, analyzing the blood count, and, if necessary, obtaining a bone marrow biopsy can all be considered as part of the evaluation.

This question can be discussed in conjunction with your oncologist.

This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.

Kevin Pho, M.D.

KevinMD.com
Twitter.com/kevinmd