High SGPT and SGOT

I recently received the results of a blood test that showed some elevations:  SGOT (59), SGPT (108) & Bilirubin, Direct (.2).  All other results normal (sugar, cholesterol, etc).  My Doctor told me that the medications I'm on do not cause these elevations.  I believe this not to be true.  I will list the DAILY dosages of each medication.  I am also stopping each one which I probably do not need.  I verified this with another physician.  Also, if these meds prove to cause these elevations, will my readings return to normal and how much damage could have occurred?:  Zyban/Welbutrin 300mg, Niaspan 2500 mg, Ambien 10mg, Skelaxin 800 mg x3, Relafen 500 mg x2 and many other vitamin supplements.  For the past 2 years I noticed these levels to be either borderline or slightly elevated (5 prior test results).  I don

[Kevin Pho, MD]

It is possible that some of the medications you are taking may lead to the liver elevations.  Abstaining from some of the medications, probably starting with the NSAID (Relafen), should be considered - as this medication can uncommonly elevate the liver enzymes.

I would also consider further testing of the liver.  Blood tests to look for hepatitis as well as an ANA and ferritin level (to look for autoimmune causes and hemochromatosis respectively) can be considered.

An ultrasound to image the liver should also be done.  

Serial monitoring of the liver enzymes can be considered, and a liver biopsy discussed if the levels continue to rise.

These options can be discussed with your personal physician, or in conjunction with a GI physician.

Followup with your personal physician is essential.

This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.

Kevin, M.D.
kevinmd_

[hbp702]

Your doctor doesn't think Niaspan could elevate liver enzymes?!

It can cause that, and even cause JAUNDICE!

Your doctor needs to read up, or learn how to use Google (took seconds to find this page):

http://cholesterol.emedtv.com/niaspan/niaspan-and-liver-problems.html

Just do a search on Google for: niaspan liver enzymes.