Medication

  Recent colonoscopy done with U.C. to 50 or 60 cm. Dx came 24 years ago. I used Cortenema intermittently, later Azulfidine for about 6 years. I stopped all meds 3 years ago.I am currently working with a homeopathic physician. In July or August, each year I get a flare up only to go into remission again in January or February. My doctor wants me to start on Azulfidine and Rowasa Enemas again. Is there any benefit to being on the Azulfidine 365 days a year when I could use the Rowasa only when I have a flare up? What are the benefits? Will the Azulfidine lessen my chances of cancer? I really don't want to take any unnecessary medication. I do appreaciate your help.RBR
Dear RBR,
Recent data has shown that in patients with chronic ulcerative colitis in remission on maintenance therapy (indefinite) have less relapses than patients who are only treated during periods of exacerbation. Although there is no definitive data to prove that maintenance therapy prevents the development of colon cancer, it seems logical to assume that chronically suppressing inflammation will decrease the chances of this occuring. There are some studies that suggest that taking folic acid on a daily basis may decrease the chances of developing colon cancer in general and  in particular in patients with inflammatory bowel disease.  Since Azulfidine interferes with the utilization of folic acid, it is usually given with folic acid supplements. Having said all that,  given the fact that your disease only extends to 50-60 cm, your risk for developing colon cancer is only slightly higher than the general population. The risk of developing colon cancer in patients with ulcerative colitis is highest in patients wtih extensive or total colitis for a period of at least 7-10 years. I hope you find this information helpful.
This response is being provided for general informational purposes only and should not be considered medical advice or consultation. Always check with your personal physician when you have a question pertaining to your health.
If you would like to be seen at our institution please call 1-800-653-6568, our Referring Physicians