Non-specific ulceration of throat and tongue

For nearly seven months my brother had had what a specialist has called non-specific ulceration of the throat and tongue.  It began with slight soreness on the left hand side.  The GP prescribed antibiotics.  Two courses did not help.On referral to a specialist, he had a laryngoscopy. The specialist said it was not cancerous, but arranged a biopsy which showed it was not. He also had a barium meal x-ray which was clear.  He had another course of antibiotics and liquid antifungal medicine, which also do not seem to be having any effect..He feels as though he has pulled the muscles in his lower jaw, has a burning pain at the back of his throat, and produces a lot of saliva. Because of the soreness, he mashes solid food to ease the swallowing, but because he is not eating half as much as usual, is losing weight.The condition is getting him down and he is becoming desperate. He is constantly on painkillers - even feels high sometimes, and often loses sleep. It is worrying me, and I wondered if you have any helpful advice. He does suffer quite badly with psoriasis. Could it be connected? I would be grateful for any information which might help. Perhaps he should seek a second opinion?

[Kevin Pho, MD]

A second opinion, perhaps with a GI specialist, would be advised.  An upper endoscopy can be performed to see how far down the ulceration goes down.  The endoscopy is a more comprehensive test than the barium swallow.  

One consideration would be oral candidiasis - which can cause the symptoms described.  Oral liquid antifungal medication may not be enough - sometimes pills, such as fluconazole, are needed.  

Other causes would be variums viruses - such as HIV, coxsackie, varicella, and herpes.  Biopsies via the endoscopy would be reasonable to ensure there are no other causes.  

Followup with your personal physician is essential.

This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.

Kevin, M.D.
Medical Weblog:
kevinmd_b

[yoshi]

is he taking any medication??
does he have acid reflux??
good vitamins may help,look into A,C,B etc