Throat Swelling...LPRD?

I underwent cardiac surgery 2 months ago and since then, I've been experiencing (intense) reflux for the first time in my life. The most concerning issue being that my throat has a tendency to swell (or at least feel like it's swollen) as a direct result. An ENT diagnosed me with LPRD and prescribed Prilosec 20mg/2 day. But, if anything, that seemed to make it worse after 2 weeks of use(is that even possible?). I've done some tests (barium swallow, st xray) but things in that dept. seem normal. Is it possible that there could be a correlation between the surgery my newfound UGI problems? More specifically, could it be my post op treatment (Plavix 75mg 1/day, Aspirin 325mg 1/day) causing this to happen? If so, what are my options? Should I give PPI's another chance? Should I follow up with a GI? Are PPI's and H2B's safe to take together? If so, would this be a recommended course? Any input would be appreciated. Thanks!

[Kevin Pho, MD]

I agree with the testing thus far.  A 24-hr pH study can be considered to confirm the diagnosis.  

It is generally safe to take PPIs and H2 blockers together.  If the pH study continues to show reflux despite maximal medical therapy, you can discuss whether surgical options are appropriate.  

Other causes of throat swelling can be considered as well.  This can include allergies leading to post-nasal drip.  

These options can be discussed with your personal physician.

This answer is not intended as and does not substitute for medical advice - the information presented is for patients education only. Please see your personal physician for further evaluation of your individual case.

Kevin, M.D.
www.kevinmd.com

[shaixhulud]

Hey Kevin,

Thanks for getting back to me. Do you think it's possible that the reflux could be triggered by my post op blood thinner therapy (Plavix 75mg w/ Aspirin 325mg daily)? It's really been the only change in my lifestyle that I can think of in recent past...besides the ASD closure. I don't drink, smoke or consume caffeine (sodas, coffee etc).

Also, is it possible for PPI's to make reflux worse?? It feels like one of those questions you might ask a doctor and then they look at you like you're crazy, but when I was on Prilosec, it only seemed to get worse as time went on.