GASTROENTEROLOGY / DIGESTIVE DISORDERS EXPERT FORUM
Transplant suitability

Transplant suitability

  My son, now nearly seventeen, became seriously ill about two
  and a half years ago.  He was admitted to a paediatric hospital
   and after about six weeks and inumerable tests received a
  diagnosis.  We have been told that he must have contracted a
   'mild' form of hepatitus (hepatitis) which his immune system successfully
  fought off.
  The problem is that his immune system then did not shut down
  and began to destroy his liver.  He has been treated continuously
  with two drugs since then and had regular biopsies and blood tests.
  After more than two years and all the associated side effects of
  depression, suppressed puberty and growth inhibition, the
  specialist has said that his condition has continued to
  deteriorate and he must have a liver transplant.  The problem
  is that the immune system is still not under control and he
  must wait until it is.  His medication was increased
  substantially about three months ago and his blood tests
  show a lessened level of immune sytem activity.  
  Is it possible that the drugs can be withdrawn without the
  immune system becoming over-active again?  I am concerned that
  each time an attempt has been made to reduce dosages, there
  has been only a temporary improvement then a reversion that
  has resulted in further incremental damage to the point that
  he is left with about 15% function.
  My son is losing heart and the enjoyment of his teenage years and
  the medication is causing bouts of severe depression.
  Is it possible that a transplant could be successful without
  the immune system being totally under control?
  Any advice or information would be greatly appreciated.  
  Thank you
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Dear Michael:
I am extremely touched by your son
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