question about Reglan

   Could you tell me what is considered long term use of reglan?
   What should be done when symptoms persist with treatment of
   reglan and prilosec, when should surgery be considered? Are
   there long term side effects of reglan or prilosec?
     Thank you
    Cathy
Dear Cathy,
Side effects of metaclopramide (Reglan) include: depression, fatigue, lethargy, galactorrhea (milk discharge from the breasts secondary to elevated prolactin levels) and extrapyramidal symptoms (dystonic reactions, muscle spasm, involuntary movements of the limbs, facial grimacing and others). Extrapyramidal symptoms usually occur within 48 hours after starting the drug. Parkinsonian type symptoms can occur within the first 6 months after starting the drug. Tardive dyskinesia can occur after brief periods on the drug but usually occur with increased duration of treatment (probably longer than 6 months).
Omeperazole (Prilosec) is generally a well tolerated drug. Common side effects include: headache, abdominal pain, diarrhea and constipation. When the drug was first released in the United States there was concern about the development of stomach tumors in rats given high doses of omeperazole. Omeperazole has now been used in Europe for prolonged periods for patients with gastroesophageal reflux disease without any serious consequence.
Nissen fundoplication (surgery) for the treatment of gastroesophageal reflux disease is indicated in patients who continue to have symptoms despite medical therapy and adherence to anti-reflux measures. It is also indicated in young patients who are concerned about being on medications for the rest of their lives. You must keep in mind that surgery carries its own set of risks and potential complications. Further testing prior to surgery may be required to exclude an esophageal motility disorder and to confirm the diagnosis of gastroesophageal reflux disease. I hope you find this information helpful.
This  response is being provided for general informational purposes only and should not be considered medical advice or consultation. Always check with your personal physician when you have a question pertaining to your health.
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