re: proton pump inhibitor

Does any of the PPI cause arrythmias or are contraindicated to heart patients? Thank you!

[DeeA]

Well, it is very possible PPI's can attribute to arrythmias, because it is listed as a adverse reaction to several PPI's. I cannot list all of them, but have listed to well known PPI's. Speak with you doctor if you are having any problems.

Dee RN,C CLTC



<b><font color="red"><h1>Prilosec</h1></font></b>

ADVERSE REACTIONS

Omeprazole delayed-release capsules were generally well tolerated during domestic and international clinical trials in 3096 patients.

In the U.S. clinical trial population of 465 patients (including duodenal ulcer, Zollinger-Ellison syndrome and resistant ulcer patients), the following adverse experiences were reported to occur in 1% or more of patients on therapy with omeprazole. Numbers in parentheses indicate percentages of the adverse experiences considered by investigators as possibly, probably or definitely related to the drug (TABLE 14).

TABLE 14  
  Omeprazole Placebo Ranitidine
  (n=465) (n=64) (n=195)
Headache
6.9 (2.4) 6.3 7.7 (2.6)
Diarrhea
3.0 (1.9) 3.1 (1.6) 2.1 (0.5)
Abdominal Pain
2.4 (0.4) 3.1 2.1
Nausea
2.2 (0.9) 3.1 4.1 (0.5)
URI
1.9 1.6 2.6
Dizziness
1.5 (0.6) 0.0 2.6 (1.0)
Vomiting
1.5 (0.4) 4.7 1.5 (0.5)
Rash
1.5 (1.1) 0.0 0.0
Constipation
1.1 (0.9) 0.0 0.0
Cough
1.1 0.0 1.5
Asthenia
1.1 (0.2) 1.6 (1.6) 1.5 (1.0)
Back Pain
1.1 0.0 0.5


The following adverse reactions which occurred in 1% or more of omeprazole-treated patients have been reported in international double-blind, and open-label, clinical trials in which 2631 patients and subjects received omeprazole (see TABLE 15).

TABLE 15 Incidence of Adverse Experiences