want to know the long term effects of prolixin on the liver

  I take prolixin a psychotropic drug and would like to know the long terms effects on the liver
Dear Jackie,
Prolixin (fluphenazine) is a psychoactive drug which belongs to the class of medications called phenothiazines. Prolixin is long acting. Phenothiazines have been associated with a pattern of liver injury called cholestasis (failure of bile to exit the liver). Cholestatic jaundice usually occurs within 3-5 weeks of starting treatment. Elevations of the liver enzyme called alkaline phosphatase and elevated serum cholesterol usually occur. Mild elevations in the liver enzymes called aminotransferases (AST and ALT) may also occur. The prognosis for full recovery is good. Nearly 75 percent of patients with cholestatic jaundice recover completely within 3 months of stopping the drug. In a few cases this may persist for over a year. However, most of these patients recover within a few years. Rarely, does this chronic syndrome progress. Treatment usually involves discontinuation of the drug and symptomatic support. I hope you find this information helpful.
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