gittelman's syndrome

what is gittelman's syndrtome?


This discussion is related to gittelman's syndrome.

[Tuckamore]

Hello,

Welcome to the Pain Management Forum of MedHelp. I am glad you found us. I had to do some research on this condition. I am sorry but I am not familiar with it. Below is information that I pulled from a trusted Medical site.

BEGIN QUOTE: "Gitelman syndrome is a rare inherited defect in the distal convoluted tubule of the kidneys. It causes the kidneys to pass sodium, magnesium, chloride, and potassium into the urine, rather than allowing it to be resorbed into the bloodstream.

People suffering from Gitelman's syndrome present symptoms which are identical to those of patients who are on thiazide diuretics.

Clinical symptoms for this disease are hypochloremic metabolic alkalosis, hypokalemia, and hypocalciuria. Hypomagnesemia is present in many but not all cases. In contrast to patients with Liddle syndrome, those suffering from Gitelman's syndrome are generally normotensive. Carriers of Gitelman's syndrome-linked mutations are often asymptomatic while some complain of mild muscular cramps or weakness expressed as fatigue or irritability. More severe symptoms such as tetany and paralysis have however also been reported. Phenotypic variations observed among patients probably result from differences in their genetic background and may depend on which particular amino acid in the NCCT protein has been mutated." END QUOTE

There are many other articles on the web related to this inherited disease. If you require more clarification or have a specific question I will return to MH later today, just ask.

Take Care,
Tuck