Gastroenterology Community
Brunner's glands with hyperplasia
About This Community:

Ask questions on Gastroenterology issues: Acid Reflux (GERD), Barretts Esophagus, Colitis, Colon/Bowel Disorders, Crohn's Disease, Diverticulitis/ Diverticulosis, Digestive Disorders and Stomach Pain.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank
Blank Blank

Brunner's glands with hyperplasia

I had an endoscopy in May this year as I was exteremly ill and was malabsorbing.  I was told I had coeliac disease (probable) and have now been gluten free for 6 months.  I was also found to have an adrenal tumour which is being investigated and have 'suspected' Postural Orthostatic Tachycardia Syndrome (POTS).

My endoscopy report reads:

'5 pieces of tissue were biopsied.

Sections of the duodenum showing a raised count of intraepithelial lymphocytes (IEL) with no villous atrophy and with moderate crypt hyperplasia.  The intraepithelial CD8 positive lymphocyte-count is more than 40 per 100 epithelial cells (40-50 IEL/100EC).  Brunners glands with hyperplasia are seen.

The appearances are in keeping with coeliac disease (marsh 2).
Evidence of ulcer or malignancy is not seen.

Note: The histological findings in coeliac disease are characteristic but not specific, a favourable response to a gluten free diet is needed for a definate diagnosis.'

I am still not absorbing, I am low on iron, b12 deficient, vit D deficient, low folic acid.  I am still unwell.  The only improvement is the severe weakness I was experiencing has lessened.

Can anyone give me their opinion on this?  What other causes may there be for the above changes other than coeliac.

Another concern for me is the statement 'Brunners Glands with hyperplasia are seen' - I have read a little about this but do not want to take it out of context (sometimes the internet info can make us worry!!!)

Many Thanks
Related Discussions
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Gastroenterology Community Resources
RSS Expert Activity
233488 tn?1310696703
Blank
Marathon Running Done Over Many Yea...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
233488 tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
748543 tn?1443740527
Blank
TMJ/TMJ The Connection Between Teet...
01/15 by Hamidreza Nassery , DMD, FICOI, FAGD, FICCMOBlank
Top Digestive Answerers
Avatar m tn
Blank
fntn
MI
168348 tn?1379360675
Blank
ChitChatNine
Avatar n tn
Blank
cnoevl21
144586 tn?1284669764
Blank
caregiver222
1340994 tn?1374197577
Blank
Caryopteris
Raleigh, NC
1530171 tn?1448133193
Blank
TheLightSeeker
London, ON