Crohn's disease can be difficult to diagnose, and can be missed by a
colonoscopy. The upper GI series would be the most reasonable next step if this is suspected.
Capsule endoscopy can also be considered if Crohn's disease is still suspected despite negative tests. A number of autoantibodies have been detected in patients with
inflammatoryInflammatory bowel disease
Ulcerative colitis bowel disease, some of which may be clinically useful for establishing the diagnosis and differentiating Crohn's disease from ulcerative colitis. Two of the most commonly used antibody tests are antineutrophil cytoplasmic antibodies (P-ANCA) and anti-Saccharomyces cerevisiae antibodies (ASCA).
These options can be discussed with your personal physician.
Followup with your personal physician is essential.
This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.
Thanks,
Kevin, M.D.
Bibliography:
Peppercorn. Clinical manifestations and diagnosis of Crohn's disease. UptoDate, 2004.