Have had Crohn's 35 yrs-dx at 25. Spent most of that time on steroids.Allergic to sulphur drugs/azathioprine;GI won't prescribe Infliximab as I have psoriasis.Various rectal haemorrhages,but no resections,inflammation spread thru small and large intestines.8 yrs ago I was put on oral methotrexate by a previous GI,25 mgs a week,helped,not fully,as I still had morning diarrohea,with mucus and blood.4 yrs ago got breast cancer and Onc refused to treat me unless I stopped the mtx - said I would die from septicaemia if I had FEC chemo along with mtx.Gastro couldn't help,said bc was life threatening and Crohn's isn't.Got new Onc who prescribed small daily doses of dexamethasone during 6 months of chemo. After a dreadful year of surgeries, chemo and radiotherapy,4 months on nutritional Frutijuice,no solid food,back onto oral mtx but it still didn't alleviate the problems.New gastro at my instigation prescribed weekly injections 15 mg of mtx,25 mg Cipro daily.I am doing brilliantly.At last consult he said I should go back onto oral mtx, but I don't understand his reasoning.He said something about did I want quality or quantity of life?!!I want both!.He is worried about long term injections of mtx,toxic effects on liver & osteoporosis as I also take Arimidex.We both agreed that with injections,at least we know what amount of mtx I am absorbing.Is anyone else on this regime that can help me decide what to do? I see him Jan 9 to sort out my meds and need some valid arguments to continue with current meds.Can't get the mtx injections unless he agrees.Any advice appreciated.Tks,Liz
Thanks for your reply. I was tested for Coeliac disease (by biopsy) when I was first dx with Crohn's. I don't feel this is an issue, as I am well on mtx. My problem is my gastro continuing to prescribe it, because of the toxic effects on the liver.
I was on methotrexate for 2 years and had no trouble with my liver. I started on the shots and moved to the oral. When your levels in your liver change they will take you off of it. You will be asked to come in and for blood work ever 4 to 6 weeks just to keep on eye on your levels. Hope this helps.
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