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Gastroenterology  (Expert Forum)
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HELP.......I NEED HELP IN ANSWERING A QUESTION.
This forum is for questions regarding Gastroenterology issues such as Acid Reflux (GERD), Barretts Esophagus, Colitis, Colon/Bowel Disorders, Crohn's Disease, Diverticulitis/Diverticulosis, Digestive Disorders, IBS, Stomach Pain.

HELP.......I NEED HELP IN ANSWERING A QUESTION.

by wener_1, Dec 30, 2001 12:00AM
is there any cure for c-diff?
if there is any that you know of , please reply.
Member Comments (1)

by imkindly, Dec 31, 2001 12:00AM
Clostridium difficile is caused by some antibiotics.
Here's an article from
http://archinte.ama-assn.org/issues/v161n4/abs/ira00037.html

Clostridium difficile–Associated Diarrhea  

Eleftherios Mylonakis, MD; Edward T. Ryan, MD; Stephen B. Calderwood, MD

Clostridium difficile causes 300,000 to 3,000,000 cases of diarrhea and colitis in the United States every year. Antibiotics most frequently associated with the infection are clindamycin, ampicillin, amoxicillin, and cephalosporins, but all antibiotics may predispose patients to C difficile infection.
The clinical presentation varies from asymptomatic colonization to mild diarrhea to severe debilitating disease, with high fever, severe abdominal pain, paralytic ileus, colonic dilation (or megacolon), or even perforation. The most sensitive and specific test available for diagnosis of C difficile infection is a tissue culture assay for the cytotoxicity of toxin B. However, this test takes 1 to 3 days to complete and requires tissue culture facilities. Detection of C difficile toxin by means of enzyme-linked immunoassay is more rapid and inexpensive. A minority of patients may require more than 1 stool assay to detect toxin.

Oral metronidazole or oral vancomycin hydrochloride for 10 to 14 days are equally effective at resolving clinical symptoms; oral metronidazole is preferred in most cases because of lowered cost and less selective pressure for vancomycin-resistant organisms.

Approximately 15% of patients experience relapse after initial therapy and require retreatment, sometimes with an extended, tapering regimen. Immunity appears to be incomplete and predominantly mediated by serum IgG to toxin A. Measures for preventing the spread of the pathogen, appropriate diagnostic testing, and treatment may avert morbidity and mortality due to C difficile–associated diarrhea.

Archives of Internal Medicine 2001;161:525-533

by wener_1, Dec 31, 2001 12:00AM
To: imkindly
Thankyou for your time
and consideration in answering this question.

by CariLynne, Nov 08, 2009 07:22PM
A related discussion, C.Diff was started.
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