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High Elevated B12 and Folate, Low Iron and Globulin
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High Elevated B12 and Folate, Low Iron and Globulin

Hi,

I am 7 months out from having a transduodenal sphincteroplasty where the surgeon permanently sewed open my pancreatic and biliary sphincters due to a severe case of Sphincter of Oddi Dysfunction. Since then, my b12 and folate numbers have been consistently over the maximum amount, though I do not take B vitamins. My doctors don't seem worried, but I've read that it can be a sign of liver disease, blind loop syndrome, small intestine bacterial overgrowth (SIBO), and/or malabsorption. Prior to the surgery these levels were always in normal range. Also, since the surgery and a sepsis infection that nearly took my life, I get severe nerve, tendon, and joint pain after eating primarily proteins and am exhausted all the time. I am sick of always being the mystery diagnosis patient! Also, my iron and ferritin levels have been on the low end, though I take Slow FE and cook with an iron skillet. And, my Alpha 2 and Beta globulins are low now. Any feedback???
2 Comments Post a Comment
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1711789_tn?1361311607
Hi there!

Vitamin B12 and folate are water soluble vitamins and slightly elevated levels should not be a cause for worry, including the list of causes mentioned. The iron/ ferritin and globulin levels could be related to low dietary intake/ malsorption or secondary to a few systemic causes. The tendon/ joint pain would need to be seen by a rheumatologist or an orthopedician to rule out issues such as chronic inflammation, injuries etc. I would recommend seeking a review with your treating doctor and seeing the concerned specialist for the joint pains.
Hope this is helpful.

Take care!
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1994720_tn?1352745833
Thank you for your response. I have already seen a rheumatologist and neurologist about the strange tendon and nerve pain I've had ever since my surgery and subsequent sepsis incident. I never had these before and they are stumped. I have also read that high b12 and folate can actually mean I am not metabolizing/absorbing it well, hence they are ending up in my bloodstream at high levels. I am currently on a small intestine bacteria overgrowth (SIBO) antibiotic Xifaxin as one doctor thinks I may have SIBO which can interfere with vitamin b absorption. Is there a better b12 and folate test than the standard blood test that can accurately discern if I am deficient? Deficiencies in b vitamins can produce the symptoms I currently have--nerve/tendon pain, facial rashes, photosensitivity, high b12/folate levels, fatigue.
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