Hello - thanks for asking your question.
I'm not sure if all the symptoms are related. Your upper stomach pain is suggestive of dyspepsia (i.e. peptic ulcers, gastritis, GERD, esophagitis). Other causes would be biliary pain, pancreatitis, cancer, or irritable bowel. You have had an upper GI, esophagram, and H Pylori - all negative.
I would suggest an upper endoscopy. This is the most definitive test - it can pick up things that are missed by the barium tests you had.
Another test to consider would be a 24-hr pH study. This is to test GERD. If you are continuing to have discomfort despite nexium/protonix then a definitive diagnosis of GERD may lead to surgical options.
If everything continues to be negative (i.e. negative endoscopy, 24-hr pH test etc.), then I would consider either an abdominal ultrasound to evaluate for gall bladder disease or CT scan to evaluate the pancreas.
In terms of the frequent urination/back pain a urine test to evaluate for infection or a kidney ultrasound (looking for cysts or masses) would be reasonable next steps.
Followup with your personal physician is essential.
This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.
Thanks,
Kevin, M.D.