Increase in Enzymes

[MrsThys]

Hello - I'm on track for adjustable laparoscopic band surgery.  At my first consult in May my liver readings were AST 39, ALT 52 and ALK Phos 161.  Just had my pre-op blood tests done and the results were AST 46, ALT 100 and ALK 201. All other tests were in normal limits (Albumin 3.8, Globulin 4.0, Total Bili of 0.6) I'm concerned that even though I've lost 35 pounds since May, my enzymes have increased.  This was suprising to the surgeon since he anticipated that they decrease with weight loss.  He indicated that when he places the band that he will do a liver biopsy.  He also indicated that possibly my gallbladder was reacting to the weight loss and I may have developed stones.  I'm really nervous about this.  Any insight will be totally helpful. Thanks in advance!

[Kevin Pho, MD]

Many causes can lead to an increase in liver enzymes.  I would consider initial tests such as an abdominal ultrasound and blood tests looking for viral hepatitis.  More specialized tests can be considered - such as an ANA level or ferritin level (looking for autoimmune hepatitis and hemochromatosis respectively).  

If the ALT continues to rise, a liver biopsy can be considered for a more definitive diagnosis.  

These options can be discussed with your personal physician.

Followup with your personal physician is essential.

This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.

Kevin, M.D.
kevinmd_

[MrsThys]

Forgot to mention that I have been exercising more than I ever have in my life and have also been taking about 1500mg tylenol daily.  I don't drink alcohol.  I started feeling really run down on Monday and then had the pre-op blood tests done on Wednesday.  Could a cold/flu also elevate the liver tests?

[patsy56er]

Why so much Tylenol, it's very bad for the liver, if you are having issues with LFT's.

Patsy