Sure, each colon cleansers has different directions, but most you can use multiple times. Take a look at oxypowder. http://www.candidablog.com/a-comprehensive-oxypowder-review.php
They say you can use it on a long term basis without any problems. Some people say they have used it for a few years, and there's been no issues with taking it often.
Just make sure you look into probiotics to make sure your body has plenty of good bacteria too. Some colon cleansers seriously strip your body of both good and bad bacteria. So you have to put the good ones back.