I would comprehensively look at the lower GI tract. Inflammatory bowel disease, masses, colitis or infection can lead to the discomfort.
A colonoscopy or flexible sigmoidoscopy can be considered as a reasonable initial evaluation. Sending off the stool can also be considered to evaluate for infection. Of course, colon cancer can also be ruled out with these tests.
If there are upper GI or stomach discomfort, an upper endoscopy or upper GI series can be considered.
These options should be discussed with your personal physician or in conjunction with a GI physician.
Followup with your personal physician is essential.
This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.
Kevin, M.D.
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