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For example, the normal esophagus is lined by squamous (flattened) cells. In Barrett's esophagus, the normal lining is replaced by an abnormal lining called specialized intestinal metaplasia. Barrett's metaplasia has characteristics of both stomach tissue and intestinal tissue. In Barrett's metaplasia there are a lot of moucous producing cells - called goblet cells - that show up using a specific type of stain to differentiate it from the normal cells that don't have goblet cells and don't show up with the stain.
Overall, it means that there are changes going on within that organ that are saying the organ is not exactly healthy.