If you continue to have these symptoms and have been evaluated with an upper endoscopy and barium swallow, you may want to consider a 24-hr pH study to document the severity of the reflux. Further treatment can then be determined depending on the results.
Regarding the muscle twitching, I would check the electrolytes (i.e. calcium and potassium) as you have already done. If that is not revealing, I would consider a referral to a neurologist for further evaluation.
For the shortness of breath - there are many explanations that may be possible, including GI, cardiac, or pulmonary. Without examining you, it would be impossible to say what the next step would be. Asthma, heart conditions, and uncontrolled GERD can all cause shortness of breath.
In general, there should be no interaction between the ibuprofen and the protonix. However, you may want to discuss this with your personal physician.
Followup with your personal physician is essential.
This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.
Thanks,
Kevin, M.D.
Im 38 a athelete and mine started when I was 19 yrs old never new what it was .They tested my heart lungs asthma everything the only thing that helped in 20 years was prevacid 30mg one a day that have not found a cure yet but that made that fullness go away it`s like you can`t can`t get a good breath and your throat feels like its gonna close or does .This will get worse don`t wait and suffer 20 years like me .....
good luck