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fever undiagnosed

Hi,
I live in India.My mother has type2 diabetes since 8 yrs.recently since a monh almost she is having high grade fever for which diagnois couldn be made .all the tests are normal including complete CT scan with no traces of devolping cancerous cells anywhere.Malaria and typhoid are also ruled out since no improvement is shown even on taking respectice medications of the two.Please help what could be the cause.She has Diabetes and is 66 yrs old ...so undiagnosed fever could be dangerous for her
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Avatar universal
hi there,
The blood infection seems to have cured by now since repeated blood culture test is not showing any signs now .There is a change in the fever trend though but it has not gone completeley,Previously we had to give her 3-4 paracetomols now it has reduced to one or so but if we  dont give her that at high till evening fever is still reaching upto 101 deg.Also the lung had got infected and the chest x-ray was showing pleural effusion.treatment for that was going on and it has also improved with very less showing now in subsequent xrays.No other organ is infected as tests for the same have been done ,but why is the fever not going completely....pls advise what may me the reason if possible and what to do...?
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Avatar universal
Some strains of staph are resistant to ATBs; I don't know what strain has been identified in your mother's case.  Most strains will respond to ATBs.  

What to do now?  Well, all you can do is wait and see how she responds to the ATBs; hopefully good.  Blood infections are very serious and can take time to resolve, so I don't think her recovery will be quick.    
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Avatar universal
There's some new update....yesterday the blood culture test report of my mother has come (it was previously done too when she was on antibiotics..at that time it came negative) but yesterday the report showed that she has caught infection in blood.
somewhat 'staphylococcus' is the name of  bacteria ,antibiotics are started but she already has respiratory tract infection .and i've searched  this bacteria is antibiotic resistant.is it true?.so far she seems to be fine except same fever trend ...no low BP ...but
what to do now...?
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Avatar universal
I am doubting cancer based on my professional experience; I am an Oncology nurse.  If testing, scans, etc. she has had already to rule out cancer are clearing I would go in the direction of something autoimmune and/or infectious.  

In my opinion, she should consult an ID Specialist.  
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Avatar universal
One thing i would like to ask all who are having doubt of cancer is that firstly i 've heard fever does'nt usually appear in cancer untill its in advanced stage obviously where its visible enough to impact other organs, as it would have been easily caught up in so much screenings going on.Secondly so far i dont think  there's any weight loss issue which could have been again signified sign of  cancer.So where should she taken to  next any infectitious disease specialist first or cancer specialist?
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Avatar universal
I am living in Pune(Maharashtra) state but my mother lives in Indore(Madhya Pradesh)
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Avatar universal
I HIGHLY doubt this is cancer.  

There are ID Specialists that exist in India.  I would look into having your mother referred to one.  In my opinion could be something autoimmune and/or infectious. What part of India are you in?  
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Avatar universal
Well, it does seem to be strange, especially when everything come backs normal. The things that would concern me is cancer, but if they ruled that out, I am unsure, but here is some things you can mention to your doctor, in which of course some might have already been ruled out:
-Cancer
-An allergic reaction
-Hormone disorders, such as pheochromocytoma or hyperthyroidism
-Connective tissue disorders, such as rheumatoid arthritis, systemic lupus erythematosus (lupus), and giant cell arthritis
-Certain drugs, including anesthetics, antipsychotics, tumor necrosis factor inhibitors (used to treat rheumatoid arthritis), anticholinergics, and overdoses of aspirin
-Damage to the hypothalamus (the part of the brain that controls temperature), as may result from a head injury or a tumor

I wish you best of luck, if I may I ask which part of India are you in, I do have a doctor in Ludhiana, so let me know.
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Avatar universal
Nope.....The MD Doctor itakes care of the things here.which infection is causing such kind of fever is yet to be traced in midst of all confusions whether itys really some infection or something else?any advice from anybody is truly welcome as i am really running tensed now....
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Avatar universal
Has she ever been referred to an ID (Infectious Disease) Specialist?  
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Avatar universal
Hi thanks for replying ...I would just brief you the complete case history as to have a better insight of how whats all happening right from the beginning .

            My mother has type2 diabetes and she takes medicines for that  along with diet maintainance.so far no complaints of high blood pressure or any other associated acomplications of it.She had been complaining of some change in her bowel habits from last 2-3 months as of having constipation some day while diarrhoe some other day.Around a month before she started having fever betwwen 101-102 deg and complained of lower left abdominal pain.The sonography of the abdominal part was instructed and it signified swelling in large intestine and possibility of sigmoid colon diverticulitis.The medications for the same were started and with that mere 2  days dosage her abdominal pain went away.But no change in fever was seen .In the meantime CT scan of the abdomen and Colonoscopy were performed , and to all shock report of both of them were pretty NORMAL.She had her urine test done which revealed urinary tract infection for which she was given antibiotics.Her blood test was also conducted and  in that everything else was normal except increase in WBC count(point to note is that Neutrophils count in was high before UTI medications but it came back in normal range later on).
           Her typhoid test is negative and she was also put on antimalarial drugs dosage for 3 days as it was suspected too keeping in mind that all other reports were coming normal.But no change in fever trend is noted till date.If given high paracetomol dose ,fever comes down completely and recurrs after 6-7 hrs and if lower dosage paracetomol is given it comes down till 99 deg only and then slowly picks up again.
One  Important thing to note is that since my nanny died of cancer.We make it a point to rule out its possibility too but complete body scan is done and no trace of any devolpment of cancerous cells could be made anywhere.    
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Avatar universal
Hi, how high is the temperature? Usually if there is a fever that means the body is trying to fight an infection. Did they do any blood work, to see white blood cells and so on? But anything over 101-102 is moderate but you would definitely want to go to the doctor. How is her diet, is she following a strict diet?
Other conditions can cause a fever, including allergic reactions; autoimmune diseases; trauma, cancer; excessive exposure to the sun; intense exercise; hormonal imbalances; certain drugs; and damage to the hypothalamus. When an infection occurs, fever-inducing agents called pyrogens are released, either by the body's immune system or by the invading cells themselves, that can trigger the resetting of the thermostat. In other circumstances, the immune system may overreact (allergic reactions) or become damaged (autoimmune diseases), causing the uncontrolled release of pyrogens. A stroke or tumor can damage the hypothalamus, causing the body's thermostat to malfunction.
How long a fever lasts and how high it may go depends on several factors, including its cause, the age of the patient, her overall health. Most fevers caused by infections are acute, appearing suddenly and then dissipating as the immune system defeats the infectious agent. An infectious fever may also rise and fall throughout the day, reaching its peek in the late afternoon or early evening. A low-grade fever that lasts for several weeks is associated with autoimmune diseases.
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