Low Ue3 and thick placenta

Hello,

I have a few semi complicated questions. First my intergrated screen at 15 weeks was abnormal. All values were in the average range except for the Ue3, it was at 0.3 MoM when a normal is 1.0, I had a level 2 ultrasound that showed no abnormalities and an amino that showed normal 46XX and a negative SLOS testing. So I am still concerned about why the Ue3 level is so low. Then at 21 weeks I had another ultrasound and was told that the placenta is thick. I am wondering if these two are related and what the possible outcomes may be? I have also just developed a strange facial rash, that is not itchy, but red and blotchy and a bit swollen. Should I be concerned?
thanks

[Lisa Kessler, MS, CGC]

It can be difficult when something unexpected comes up during a pregnancy.  Low unconjugated estriol (uE3) is associated with Down syndrome and Smith-Lemli-Opitz syndrome, and you mentioned that your testing for these were negative.  Low unconjugated estriol is also associated with placental steroid sulfatase deficiency, an X-linked condition that is characterized by ichthyosis (a skin disorder which causes dry, fish-like scales on the skin) surface), and other unknown problems.  I do not know of any relationship with the rash that you are describing or with the thickness of the placenta.  If you have not already, you may want to consult with a Maternal Fetal Medicine specialist to discuss your blood work and your ultrasound results.  Your OB/GYN may have a recommendation, or the Society for Maternal Fetal Medicine website has a physician finder that can help you locate someone in your area.  Best wishes to you.