MS gene

I read online that they identified a gene that is linked to Multiple Sclerosis, which my mom was diagnosed with in 2001.  From what I've read, I appear to have all of the risk factors - female, close family history, live in an industrialized area (suburbs of a city with manufacturing plants), and live in the northern US.  Is there a genetic test available yet for this gene?  Should I be screened for it?  I am in the early age-range where the disease occurs.

[Lisa Kessler, MS, CGC]

You have asked some important questions.  Multiple sclerosis (MS) is a complex condition most likely caused by the interaction of multiple genes and environmental factors.  

Recently, there have been studies that have found genetic variations that are more common in people with MS than in people without MS.  IL2RA and IL7RA and those in the HLA locus are genetic risk factors for multiple sclerosis.   However, it is unlikely that these genes alone cause MS.  There is not clinical genetic testing available for MS at this time.  However, research is testing is available through Vanderbilt University Medical Center Center for Human Genetics Research.  You can contact the lab directly for more information about the research at [phone] or (1-888 ) 717-4319.  

As you know, MS is a condition that affects the central nervous system by interfering with myelin, the protective coating around our nerves.   Symptoms of MS include difficulty controlling muscles, and problems with vision and balance.  Someone who has one parent with MS, has a 2-3% chance of also having this condition.  This risk is increased compared to someone in the general population who has 0.2% of having MS.