Multiple Sclerosis

Greetings.  Can you provide use with any information about the development of genetic screening for MS ?   We're a very active forum here, and always wanting to learn more.

My best,
Lulu
Co-cl, MS forum

[Jordanna Joaquina, MS, CGC]

Current research is examining a number of candidate genes that may contribute to the development and symptoms of MS.

Researchers have identified that a common variation of the HLA-DRB1 gene called DRB1*1501 may cause susceptibility to MS in some people. However, it is not yet understood how this variation contributes to MS. HLA-DRB1 is part of a family of genes called the human leukocyte antigen (HLA) complex located on chromosome 6. There are many different variations of HLA genes, and they all function to determine and govern why we are different and how our immune system reacts.

Researchers have identified at least three other genes (PTPRC, CD24, and IL7R) that cause susceptibility to MS in some families.

Researchers are also looking at single nucleotide polymorphisms (SNPs), which are small variations in a single "letter" of DNA that can be found throughout our entire genetic make-up. Some researchers have proposed that specific SNPs may influence the risk to develop MS in some people.

Clinical testing is not yet available for susceptilibilty to MS. There is some SNP testing available. Many health professionals feel that this SNP information is of limited or no clinical use at this time.

Hope you find this information useful!