I am interested in specifically a 13/14 translocation. Is it possible for a 13/14 translocated male to create a Trisomy 13 baby? What type of results will a 13/14 translocated male have from reproducing? Thanks so much!
The 13;14 Robersonian translocation is the most common translocation seen in humans with an incidence of about 1 in 1,100 people.
A carrier parent (male or female) has an approximate 1% chance with each pregnancy to have a liveborn child with trisomy 13.
A carrier parent (male) may also have a risk (athough most likely very small) with each pregnancy to have a liveborn child with UPD (uniparental disomy) 14. Uniparental disomy (UPD) occurs when an individual receives two copies of a chromosome, or part of a chromosome, from one parent and no copies from the other parent. Paternal UPD14 is when both copies of chromosome 14 are inherited from dad, and there is no maternal copy. Paternal UPD14 is a disorder chararcterized by skeletal abnormalities, joint contractures, abnormal facial features, and developmental delay/mental retardation.
We recommend that any individual with a translocation meet with a medical geneticist for evaluation and genetic professional for risk assessment. A medical geneticist can be found at the American College of Medical Genetics website. A genetic counselor can be found at the National Society of Genetic Counselors website or through companies like mine, AccessDNA. Hope this information is helpful!
Copyright 1994-2017MedHelp International.All rights reserved. MedHelp is a division of Aptus Health.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. Med Help International, Inc. is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.