Genetic Disorders Expert Forum
hla-b27 Gene
About This Forum:

Questions in the Genetics Forum are being answered by medical professionals and experts. This forum is for questions and support regarding a person’s predisposition to a variety of medical conditions such as Ashkenazi Jewish Diseases, Bleeding Disorders, Blood Clotting Disorders, Cancer Genetics and Hereditary Cancer Syndromes, Chromosome Abnormalities, Congenital Birth Defects, Cystic Fibrosis, Family History, Fragile X Syndrome, Infertility, Newborn Screening, Rare Genetic Disorders, Prenatal Screening and Testing.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
This expert forum is not accepting new questions. Please post your question in one of our medical support communities.
Blank Blank

hla-b27 Gene

Hello, I have the Hla-B27 gene and had Iritis and Ankleosingspondalitis (I think thats how you spell it) 8 years ago. AK went into remission 1 year ago. I got Vitiligo on my back and side 2 years ago. The question here is would Anxiety have anything to do with the gene or problems I have? I have to be on Zanax (small amounts) and Lexapro to keep my panic attacks from happening. Not a lot of stress in my life? My belirubin cound came back a little high and the doctor says I have gilberts disease. Whats next? Does anyone have simular problems and does it all have to do with the gene?
Related Discussions
264002_tn?1193282555
It sounds like you have lots going on, and it is natural to want to find out if the various problems that you are experiencing have a common cause.  I could not find any reports of the HLA-B27 allele associated with increased anxiety or Gilbert’s disease.  As you know, the HLA – B27 allele causes an increased risk to develop ankylosing spondylitis, a form of chronic inflammation of the spine and of particular joints in the spine.  As you mentioned, it can also cause problems with the eyes called Iritis.   In addition to HLA-B27, there are most likely other genetic and environmental factors associated with this condition.  

Gilbert’s syndrome is generally considered to be autosomal recessive.  Gilbert’s syndrome has been described as benign and does not require treatment or long-term medical attention.   As you have explained, it causes a mild increase in bilirubin.  The reason that the diagnosis may be important is because the increased bilirubin may be mistaken for a sign of liver disease.  Gilbert syndrome is characterized by normal liver function tests, normal liver histology, a delay in clearing bilirubin from the blood, and mild jaundice that can be variable.    
Blank
Continue discussion Blank
MedHelp Health Answers
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
RSS Expert Activity
242532_tn?1269553979
Blank
Emotional Eating: What Your Closet ...
Jul 09 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
This is Driving Your Emotional Eati...
Jul 02 by Roger Gould, M.D.Blank
5856747_tn?1403352282
Blank
Sleep Apnoea
Jun 28 by Andrew John Rynne, MDBlank