Genetic Disorders Expert Forum
positive for two copies of A1298C
About This Forum:

Questions in the Genetics Forum are being answered by medical professionals and experts. This forum is for questions and support regarding a person’s predisposition to a variety of medical conditions such as Ashkenazi Jewish Diseases, Bleeding Disorders, Blood Clotting Disorders, Cancer Genetics and Hereditary Cancer Syndromes, Chromosome Abnormalities, Congenital Birth Defects, Cystic Fibrosis, Family History, Fragile X Syndrome, Infertility, Newborn Screening, Rare Genetic Disorders, Prenatal Screening and Testing.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
This expert forum is not accepting new questions. Please post your question in one of our medical support communities.
Blank Blank

positive for two copies of A1298C


Hi, my name is Grisel. I am a healthy 42 years old woman, with no children. I lost two pregnancies one last year, the other three month ago both at 6 weeks. My doctor can no find any reason. He told me maybe is my age, no enough quality in my eggs. But a blood test said I am positive for two copies of A1298C mutation. He did not say any thing about this issue. Could be this the cause for my lost? Thanks for your attention.
My regards
Related Discussions
886824_tn?1253740254
The A1298C gene variant is found in the MTHFR gene. This gene is important in the metabolism of homocysteine, an important amino acid.

Having two variants/mutations in the MTHFR gene, such as A1298C, can cause elevated homocysteine levels. Elevated homocysteine levels have been implicated in many health issues including pregnancy loss and other pregnancy-related complications. However, these risks may not be increased in the presence of normal homocysteine levels. A blood test can be performed that measures plasma homocysteine levels.

To date, research has been mixed on how strong the association between A1298C and pregnancy loss is, causing debate on what to do clinically about it. We recommend that you meet with a perinatologist for consultation and evaluation. We wish you the best.
1 Comment
Blank
Avatar_n_tn
A related discussion, mthfr was started.
Blank
Continue discussion Blank
MedHelp Health Answers
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
RSS Expert Activity
242532_tn?1269553979
Blank
The 3 Essentials to Ending Emotiona...
Sep 18 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Control Emotional Eating with this ...
Sep 04 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Emotional Eating Control: How to St...
Aug 28 by Roger Gould, M.D.Blank