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Genetics (Expert Forum)
Chance of having another baby with trisomy 13
Answered by
Lisa Kessler, MS, CGC - Hereditary Disorders, hemochromatosis, Patient Outreach
DNA Direct
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Chance of having another baby with trisomy 13
by Choquita, Apr 11, 2008 10:04PM
Hi, I am going to have a D&E tomorrow as my fetus of 15 months has trisomy 13. I had a CVS that detected that.
I am 44 years now and in Jan. 2009, 45. I know that trisomy 13 occurs with age. What are my chances of having another baby with trisomy 13 if I try again? I cried a lot and depressed however I have to move on as I have a 4 years healthy girl I conceived at 40? Is true that trisomy 13 occurs due to translocation? Should I go see a genetic specialist to find out if my husband and I suffer of translocation?
Appreciate your response,
Sincerely
I am 44 years now and in Jan. 2009, 45. I know that trisomy 13 occurs with age. What are my chances of having another baby with trisomy 13 if I try again? I cried a lot and depressed however I have to move on as I have a 4 years healthy girl I conceived at 40? Is true that trisomy 13 occurs due to translocation? Should I go see a genetic specialist to find out if my husband and I suffer of translocation?
Appreciate your response,
Sincerely
Doctor's Answer
by Lisa Kessler, MS, CGC, Apr 21, 2008 07:22PM
, Apr 21, 2008 07:22PM
I am so sorry for your loss. It sounds like an extremely difficult situation for you and your family.
As you know, trisomy 13, also called Patau Syndrome, occurs in about 1 in 5,000-10,000 live born infants. Trisomy 13 is generally caused by an extra copy of chromosome #13 (three copies of chromosome #13). Typically, we have 2 copies of each of our chromosomes.
It is very unusual for a family to have a second child with Trisomy 13. This can occur when a baby has Trisomy 13 due not to a complete extra copy of chromosome 13, but rather due to a rearrangement of piece of chromosome 13 with another chromosome. This is called a translocation which can sometimes run in families. If you had a karyotype from this pregnancy from your CVS, then this test result would be able to determine if a translocation was present.
If there is no translocation present, your actual risk for another pregnancy to be affected with a chromosome abnormality is dependent on how old you will be when you deliver. For example, if you will be 45, it is estimated at about 1 in 20.
It may help to meet with a genetic counselor to discuss the chances that a future pregnancy may have a chromosome problem. You can find a genetic counselor through the NSGC (National Society of Genetic Counselors) website. Best to you and your family.
As you know, trisomy 13, also called Patau Syndrome, occurs in about 1 in 5,000-10,000 live born infants. Trisomy 13 is generally caused by an extra copy of chromosome #13 (three copies of chromosome #13). Typically, we have 2 copies of each of our chromosomes.
It is very unusual for a family to have a second child with Trisomy 13. This can occur when a baby has Trisomy 13 due not to a complete extra copy of chromosome 13, but rather due to a rearrangement of piece of chromosome 13 with another chromosome. This is called a translocation which can sometimes run in families. If you had a karyotype from this pregnancy from your CVS, then this test result would be able to determine if a translocation was present.
If there is no translocation present, your actual risk for another pregnancy to be affected with a chromosome abnormality is dependent on how old you will be when you deliver. For example, if you will be 45, it is estimated at about 1 in 20.
It may help to meet with a genetic counselor to discuss the chances that a future pregnancy may have a chromosome problem. You can find a genetic counselor through the NSGC (National Society of Genetic Counselors) website. Best to you and your family.
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