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Genetics (Expert Forum)
Factor v Leidon
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AccessDNA
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Factor v Leidon
by harper94uk, Jun 09, 2009 08:48AM
I have Factor V Leidon diagnosed a few years ago after i flew from the UK to Menorca. I was taking a birth control pill which was to help with my skin and spots i had got a DVT.
After this i got pregnant and had to terminate. I was told then (2 years later) that i had factor 5 Leidon.
I then got pregnant a year or so later and decided to continue with pregnancy, i had to inject everyday to thin my blood so that the placenta didnt clot.
I was told that i had got this from my parents, so they were tested including my sisters but none of them had any clotting problems or have anything in blood to say where i had got it from.
Any help as i am confused as to where or how i have it and can it be passed onto my child who has special needs and are in the middle of trying to find out what condition she has.
After this i got pregnant and had to terminate. I was told then (2 years later) that i had factor 5 Leidon.
I then got pregnant a year or so later and decided to continue with pregnancy, i had to inject everyday to thin my blood so that the placenta didnt clot.
I was told that i had got this from my parents, so they were tested including my sisters but none of them had any clotting problems or have anything in blood to say where i had got it from.
Any help as i am confused as to where or how i have it and can it be passed onto my child who has special needs and are in the middle of trying to find out what condition she has.
Doctor's Answer
by Jordanna Joaquina, MS, CGC, Jun 11, 2009 05:47PM
, Jun 11, 2009 05:47PMTo: harper94uk
Factor V Leiden is caused by a specific mutation called Arg506Gln in the F5 gene.
Factor V Leiden is inherited in an autosomal dominant pattern. The risk of developing a clot in a blood vessel depends on whether a person inherits one or two copies of the Factor V Leiden mutation from their parents. In the general population, the risk of developing an abnormal blood clot is about 1 in 1,000 people per year. Inheriting one copy of the F5 gene mutation (from one parent) increases that risk to 4 to 8 in 1,000. People who inherit two copies of the mutation (one from each parent) may have a risk as high as 80 in 1,000.
We hope this information is helpful. Regarding your daughter's special needs, she may benefit from meeting with a medical geneticist for evaluation. A medical geneticist can be found at the American College of Medical Genetics website.
Factor V Leiden is inherited in an autosomal dominant pattern. The risk of developing a clot in a blood vessel depends on whether a person inherits one or two copies of the Factor V Leiden mutation from their parents. In the general population, the risk of developing an abnormal blood clot is about 1 in 1,000 people per year. Inheriting one copy of the F5 gene mutation (from one parent) increases that risk to 4 to 8 in 1,000. People who inherit two copies of the mutation (one from each parent) may have a risk as high as 80 in 1,000.
We hope this information is helpful. Regarding your daughter's special needs, she may benefit from meeting with a medical geneticist for evaluation. A medical geneticist can be found at the American College of Medical Genetics website.
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