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Genetics (Expert Forum)
chromosome translocation
Answered by
AccessDNA
Welcome to the Genetics Forum! Questions in the Genetics Forum are being answered by genetic experts from AccessDNA. This forum is for questions and support regarding a person’s predisposition to a variety of medical conditions such as Ashkenazi Jewish Diseases, Bleeding Disorders, Blood Clotting Disorders, Cancer Genetics and Hereditary Cancer Syndromes, Chromosome Abnormalities, Congenital Birth Defects, Cystic Fibrosis, Family History, Fragile X Syndrome, Infertility, Newborn Screening, Rare Genetic Disorders, Prenatal Screening and Testing.
This forum is for questions and support regarding a person’s predisposition to a variety of medical conditions such as Alzheimer’s Disease, Blood-clotting Disorders, Breast Cancer, Cystic Fibrosis, Diabetes, Marfan Syndrome, Ehlers-Danlos Syndrome, etc.
chromosome translocation
by ekssekias, Aug 15, 2009 06:13AM
Hello, after 5 miscarriages, we got to know that my husband has a reciprocal translocation between chromosome 11 and 22. i underwent one pgd session that resulted in a neutral reading (no results were given on 8 embryos). now we have given up doing the pgd for a while.
my question is, what are my chances of having a natural pregnancy without pgd, knowing that my husband is a crrier of this translocated chromosome?
thank you so much for your advice.
my question is, what are my chances of having a natural pregnancy without pgd, knowing that my husband is a crrier of this translocated chromosome?
thank you so much for your advice.
Doctor's Answer
by Jordanna Joaquina, MS, CGC, Aug 17, 2009 11:34AM
, Aug 17, 2009 11:34AMTo: ekssekias
We are sorry for your losses and lack of useful information from PGD. In about 5% of couples with recurrent pregnancy losses, one member has a chromosome translocation.
The risk to have an adverse pregnancy outcome or a child with a chromosome abnormality is based on the exact chromosome translocation (for example - the exact break points) and which member of the couple (mom or dad) has the translocation. We recommend that you meet with a genetic counselor, who provide a more accurate risk assessment based on your husband's exact chromosome translocation between chromosomes 11 and 22 and family history. We wish you and your husband the best.
The risk to have an adverse pregnancy outcome or a child with a chromosome abnormality is based on the exact chromosome translocation (for example - the exact break points) and which member of the couple (mom or dad) has the translocation. We recommend that you meet with a genetic counselor, who provide a more accurate risk assessment based on your husband's exact chromosome translocation between chromosomes 11 and 22 and family history. We wish you and your husband the best.
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