Hello,
The proper work up for irregular bleeding in a
womanWomen's way over 35 would include ruling out pregnancy, checking for an endocrine abnormality (e.g., thyroid hormone changes), assessing for structural lesions within the uterus (like endometrial polyps/fibroids usually by office hysteroscopy--i.e., looking inside the uterus with a small camera--or sonohysterogram--instilling saline into the uterus while simultaneously having a ultrasound), considering anovulation (not ovulating monthly reflective of perimenopause) and performing an endometrial biopsy to look for abnormal tissue inside the uterus (e.g., endometrial hyperplasia or cancer). With those results proper treatment can be instituted.
In your situation an endometrial biopsy will be critical because your obesity and use of Tamoxifen put you at risk for have precancerous or cancerous changes to your endometrium.
Best regards,
Dr. Downing