This forum is for questions and discussions relating to HIV exposure and risks, living with HIV, HIV prevention, HIV testing, HIV transmission, HIV treatment. All questions will be answered by a medical expert from FreedomHealth.
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HLA-DR4 is a cell surface receptor encoded by the human leukocyte antigen (HLA) complex on chromosome 6. HLA were originally defined as cell surface antigens that mediate graft-versus-host disease, which resulted in the rejection of tissue transplants in mismatched donors. HLA-DR4 is also involved in some autoimmune conditions such as rheumatoid arthritis, systemic lupus erythematosus, phemphigus, obstructive hypertrophic cardiomyopathy, IgA nephropathy, and polymyalgia rheumatica. It is associated to different ethnic groups, including Askenazi Jews.
Cases of false positive results of HIV tests have been associated to the presence of HLA-DR4, not false negative. The fact that all your tests were negative, there is no reason for you to be concerned as your results are conclusive, regardless of the fact that you might carry the HLA-DR4 receptor.
It has nothing to do with the ability of you being able to produce HIV antibodies, but it has to do with a cross-reaction specifially seen in HIV Duo tests where a false positive reaction can sometimes occur. No false negative test results have been reported in this cases. I can assure you that your negative test results are fully conclusive.
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