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Hiv post-exposure prophylaxis. how about the effectiveness of losing just one dose?
hi,sir.  1 month ago, I did something very stupid, I mean I had receptive anal sex with a hiv-positive gay man with semen directly ejaculated into my anal. I knew it was very dangerous, and took prophylaxis medication within 12 hours after the exposure(about 12h). My regimen was Zidovudine+Lamivudine+Aluvia, bid. however, on the second day after my first dose, I missed one dose that night, and on the next day , I continued to take the regular dose. I mean , on the first day, I took regular dose, 12h, bid. on the second day, I only took the morning dose, and missed the evening dose, on the third day I took the regular dose. and from then on, I completely finished the 28 days regimen. Even if I began to calculate the initial time on the third day, and ignored the 3 doses I'd taken beforehand, it was still within 72h. my question was (1) considering my situation, what about the prevention effectiveness? the preventive effectiveness could reach 100% or not? Did the one miss have a big impact on the prevention effect? (2) when should I calculate the initial time of my first dose, from the very beginning or from the second time I restarted my regular doses(after that evening miss)? urgent for your reply...
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Avatar_universal
It's only has an 86% effective rate with 100% compliance.
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but I missed one dose, did it have a big impact on the effectiveness? I was so warried about it, please help me.
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Your risk was low to begin with. I doubt that it has much of an impact just one dose.
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sir, I had repetive anal sex with a HIV-positive gay man without a condom.and he ejaculated into my anal..I thought it was extremely dangerous... u meant that losing one dose would significantly reduce the  whole effectiveness? dose it has a 50% effecitve rate? I beg your reply, sir. I'm now really worried about it ...plz help me.
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I'm sorry for not reading your correctly. You are right that is one of the highest risks that you knowingly took.  ". I knew it was very dangerous," You are worried now? worrying now is not going to change a thing. Don't miss anymore doses.
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thanks teak, for your reply, since I've finished the 28 days regimen, with only one dose missing on the second day night, I want to make sure that just losing one dose would significantly reduce the effectiveness? Given my situation, dose it have a 50% effective rate... or how much rate dose it have...
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I would have finished taking it till they were all gone.
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sorry teak, I didn`t quite understand your reply, would you please just tell me the truth... dose it have no preventive effect at all?? just one dose meant that prevention totally failed?? I really BEG your reply... if drug prevention failed, I would be 100% infected, please, help me. what should I do right now...
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Did you take the missed dose?
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no, i forgot to take drugs on the second day night, and on the next day, i started again, 12h, bid. my regimen was Zidovudine+Lamivudine+Aluvia, i mean, i missed one dose of  Zidovudine+Lamivudine+Aluvia...you mean I should add one dose more on the end?
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That would have been the smartest thing to do.
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thanks, teak, I indeed took one more dose at the end. lose one dose, but add one dose at the end... then what was the effective rate? could it reach 80%? BEG ur reply.
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All you need is the test results. 3 months after your last dose will give you your conclusive negative test result. Start using condoms and good luck.
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thanks, Teak, u mean, it may be effective, right? I still have a chance that I didn't get infected, right?
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Yes there is a chance you never got infected.
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sorry to bother you, Teak, I still want to make sure that, as far as u concerned, my infection rate is high or low, considering my situation-- taking prevetion drugs, losing one dose, and adding one dose at the end...I doubt whether I still have a very high chance of getting infected or not...
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Your risk was HIGH and you increased your chance by having multiple exposures.
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