Aa
Aa
A
A
A
Close
Avatar universal

Viral Load

Does anyone know if the viral load that you're infected with (if you're infected) has anything to do with how long it takes to seroconvert and produce detectable antibodies?  Like, if you're infected with a lower viral load, will it take longer to develop detectable antibodies (ie. past 3 months)?
Thank you.
12 Responses
Sort by: Helpful Oldest Newest
461503 tn?1212066010
Netheir the viral load or the amount of virus introduced in the body may affect the seroconversion lenght, once the virus is inside the body it starts to replicate by millions per day, so they have nothing to do with the seroconvresion lenght. Both the Viral Load or the amount of virus introduced in the body may increase or decrease the risk of infection.

Helpful - 0
Avatar universal
I think the OP meant initial innoculum (amount of virus introduced) rather than Viral Load.
It makes no sense as it is only possible to speculate on the viral innoculum ( other than is designed experiments wich would of course not be ethical).
However I'm sure observations of seroconversion time with controlled innoculi have been made on lab chimps and macacueys (sp) when testing meds.
Helpful - 0
Avatar universal
A viral load test doesn't mean anything unless you are positive and have taken an antibody test. I have AIDS and have an undetectable viral load.

Helpful - 0
Avatar universal
In post above I mean 2 virus particles where I have written 3.

It would be interesting to know whether seroconversion time would be different for someone with:

1 A short severe ARS illness  (eg bedridden <10days nodes size of plums, full-on rash...)
2 A short mild ARS illness  (eg ambulatory 2 weeks superficial rash, pinhead nodes...)
4 A long severe ARS illness (eg bedridden >2wks nodes size of plums, full-on rash...)
5 Asymptomatic Primary HIV Infection. (no symptoms)

I understand from another Doctors' forum that symptoms are nothing to do with Antibodies.

I don't think ARS has been studieed that well and Doctors aren't really interested in symptoms so knowledge in that areaa will probably never be developed. Furthermore the time to seroconversion can never be proerly studied (under controlled lab conditions)unless known innoculums were  introduced to known hosts and bloods drawn each day until seroconversion.

In the meantime people will just have to sit out the window period.
Helpful - 0
Avatar universal

In post above I mean 2 virus particles where I have written 3.


It would be interesting to know whether seroconversion time would be different for someone with:

1 A short severe ARS illness             (eg bedridden,  2 weeks ditto      
3 A short mild ARS ilness                 (eg ambulatory, 2 weeks superficial rash, pinhead nodes ...
5 Asymptomatic Primary HIV Infection.

I understand from another Doctors' forum that symptoms are nothing to do with Antibodies.

I don't think ARS has been studieed that well and Doctors aren't really interested in symptoms so knowledge in that areaa will probably never be developed. Furthermore the time to seroconversion can never be proerly studied (under controlled lab conditions)unless known innoculums were  introduced to known hosts and bloods drawn each day until seroconversion.

In the meantime people will just have to sit out the window period.
Helpful - 0
Avatar universal
I asked THT Direct if the initial innoclum made a difference they said no. The particular guy, seermed to know his stuff.

I do seem to recall Dr Bob said it may be a factor but don't quote me on that and it's 2am here so would take until morning to look up.

I wouldn't think it would there wouldn't be much of a difference in being infected with 2 virus particles or 1,000,000 viral particles as the rate of replication is so high initially. If you compared the 3 given equivalent hosts it wouldn't take long for 3 to replicate to 1,000,000.
I guess host variability and virulence, replication speed are the key factors

Helpful - 0
Avatar universal
your viral load can be undectable. real low. there are many new infection with hiv with a undectable viral load, that is why the antibody test is used for diagnosis. you can have antibodies and be undectable. i know that terrible, but true.
Helpful - 0
Avatar universal
everyone body is different. making antibodies right, but you need to have enough of them to be dectected. the hiv test are good, but it is up to your body to react to the virus in a mature way. time is the answer . for some real quick others not so fast.
Helpful - 0
Avatar universal
go to my post and you will find the answers i got from the same question
Helpful - 0
Avatar universal
but they say you can always get a conclusive test 100% sure test after three months. The modern testing they say is sensitive enough to detect antibodies that early.

Also, in my non-medical non-expert opinion, if there is a foreign body in your system(body) like virus, bacteria etc no matter how little they are the body'll still try to fight and dispose it. This will cause antibodies to be created. So maybe the doctors are correct when they say 3 months to be sure.
Helpful - 0
Avatar universal
i did the same question and the answer is no
the viral load is a determinant in risk infection but not in the inmune system response to the virus
i was also overthinking about this because anxiety but im going to trust my exams and wait until 13 th week test , try to do the same if you are in high risk
Helpful - 0
Avatar universal
that is a great question. i dont know. what i have read is that there has not been enough studies on this.
Helpful - 0
Have an Answer?

You are reading content posted in the HIV Prevention Community

Top HIV Answerers
366749 tn?1544695265
Karachi, Pakistan
370181 tn?1595629445
Arlington, WA
Learn About Top Answerers
Didn't find the answer you were looking for?
Ask a question
Popular Resources
Condoms are the most effective way to prevent HIV and STDs.
PrEP is used by people with high risk to prevent HIV infection.
Can I get HIV from surfaces, like toilet seats?
Can you get HIV from casual contact, like hugging?
Frequency of HIV testing depends on your risk.
Post-exposure prophylaxis (PEP) may help prevent HIV infection.