Aa
worried about the HIV-O and HIV-N.
Hi,I have a unprotected sex 4 years ago. Please help me for the following questions, I want to live a better life, I am very regretful for my experience...I really really very scared about the HIV-N and HIV-O. I know these two group from HIV-1. And all over the world has few people are infected, but I still very worried about I am the one of them.
1st first question: I did 3 HIV-1/2 ab screen during these 4 years, and all of the results were non-reactive.But I still very worried about the HIV-O and HIV-N which are from HIV-1. I am so scared that the HIV-1/2 ab screen cannot detect the HIV-N and O??? Since my result is non-reactive, does it means I am not infected with HIV-N and HIV-O? My tests were done at NorthEast medical services.
My second question is, since my test are non-reactive , why it says: A non-reactive result diicates HIV-1 and HIV-2 antibodies have not been found in this patient specimen. 1 non-reactive result, however, does not preclude previous exposure or infection with HIV-1 and/ or HIV-2.? Why it says so? Does it mean the window period or HIV-N and HIV-O?
please answer the above two quesiton, thanks a lot.....
1st first question: I did 3 HIV-1/2 ab screen during these 4 years, and all of the results were non-reactive.But I still very worried about the HIV-O and HIV-N which are from HIV-1. I am so scared that the HIV-1/2 ab screen cannot detect the HIV-N and O??? Since my result is non-reactive, does it means I am not infected with HIV-N and HIV-O? My tests were done at NorthEast medical services.
My second question is, since my test are non-reactive , why it says: A non-reactive result diicates HIV-1 and HIV-2 antibodies have not been found in this patient specimen. 1 non-reactive result, however, does not preclude previous exposure or infection with HIV-1 and/ or HIV-2.? Why it says so? Does it mean the window period or HIV-N and HIV-O?
please answer the above two quesiton, thanks a lot.....
Hi, are you here Teak? I have a few more questions. 4years ago, I had a unprotected sex. I did three HIV tests during these years. ALL came back with NON-reactive. My tests were HIV-AB screen.But it says: "A non-reactive result diicates HIV-1 and HIV-2 antibodies have not been found in this patient specimen. A non-reactive result, however, does not preclude previous exposure or infection with HIV-1 and/ or HIV-2." Why it says so? Does it mean the window period ? Or it means they cannot find HIV-P, HIV-N and HIV-O?
My 2nd quesiton is, SInce you said HIV-N,O,P can be deteced by ELISA. So, my tests only find Antibodies,but not atigen. Are them ELIsa? Can 3rd generation ELISA find HIV-P N O?
I konw I ask a lot, but could you please explain the questions step by step please? THanks a lot!!
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You are fine Your symptoms are not even close to an ARS seroconversion, and your tests are fine.
HI, Teak. I see a hope from your view. Please tell me that Since I have non-reactive result, Does it mean that I am not infected with HIV-N and O and P??? I just did three HIV tests . Which are the same test HIV-1/2 AB screen....I don't konw if it a ELISA or not? But Can I say I am not infected with HIV-N O P?
Frankly I really don't care if you agree or not. The guidelines are 3 months had have been since 2004. As for symptoms, symptoms won't tell you anything about your status. HIV has no specific symptoms.
Teak,
I understand that as moderators, CDC, governments have to set up a standard such as the window period inn order to control people and not fuel chaos. But I dont agree that you guys should blindly tell people 3 months when that is not 100% especially with this highly mutant virus, host response or other few factors that could affect validity of the tests WHEN signs/symptoms (not talking about pains, or a sore throat, or people with symptoms 1 day after risk); cd4/cd8 invertion, thrush, persistent fever, rash doesnt itch trunk, night sweats not from fever, hot flashes, mouth ulcers..in healthy people who never had anything like this and it happens after sexual activity.
I understand that as moderators, CDC, governments have to set up a standard such as the window period inn order to control people and not fuel chaos. But I dont agree that you guys should blindly tell people 3 months when that is not 100% especially with this highly mutant virus, host response or other few factors that could affect validity of the tests WHEN signs/symptoms (not talking about pains, or a sore throat, or people with symptoms 1 day after risk); cd4/cd8 invertion, thrush, persistent fever, rash doesnt itch trunk, night sweats not from fever, hot flashes, mouth ulcers..in healthy people who never had anything like this and it happens after sexual activity.
Don't be hijacking another person post. If you have a question post in your own thread.
http://www.cdc.gov/globalaids/Resources/pmtct-care/docs/TM/Module_6TM.pdf
Page 11
#4
In an adult, a positive HIV antibody test result means that the person is infected, a person with a negative or inconclusive result may be in the “window for 4 to 6 weeks but occasionally up to 3 months after HIV exposure. Persons at high risk who initially test negative should be retested 3 months after exposure to confirm results
Page 11
#4
In an adult, a positive HIV antibody test result means that the person is infected, a person with a negative or inconclusive result may be in the “window for 4 to 6 weeks but occasionally up to 3 months after HIV exposure. Persons at high risk who initially test negative should be retested 3 months after exposure to confirm results
I am just saying that scientists, physicians and people interested in HIV KNOW that due to mutation and RT errors HIV variants with changes in the genome or structure won't necesarily test positive; and rare cases are going to happen especially with exposures in countries where infection is not well established. I write this because I pretty much could be one of those cases at 14 months after risk in Colombia; and if you ask me I am 1000% sure I have HIV not picked up by tests. All of my hope is in a viral culture with isolation of the isolates. Fortunately, a scientist at the Institute of Human Virology is trying to work on my blood; and I also have contacted the Chief of HIV/Aids program at UM and his specialty is molecular virology. I hope I can see him soon.
"This expanding genetic diversity raises concerns over the ability of diagnostic assays to detect unique CRFs. Antibody-detecting assays and NAT rely on the presence of specific epitopes and genetic sequences, respectively, for HIV detection. Strain variants that do not carry these specific epitopes and sequences, or present other reactive ones, will produce inaccurate assay results.[60
http://www.medscape.com/viewarticle/725476_6
"This expanding genetic diversity raises concerns over the ability of diagnostic assays to detect unique CRFs. Antibody-detecting assays and NAT rely on the presence of specific epitopes and genetic sequences, respectively, for HIV detection. Strain variants that do not carry these specific epitopes and sequences, or present other reactive ones, will produce inaccurate assay results.[60
http://www.medscape.com/viewarticle/725476_6
Jama The Journal Of The American Medical Association (1996) give me a break, try some other outdate article.
Yes, emerging strains will continue to emerge and crossreaction might or not will occur. There will be people who unfortunately won't be treated until late stages of Aids because of false negatives.
"The discovery of highly divergent strains of human immunodeficiency virus (HIV) not reliably detected by a number of commonly used diagnostic tests has underscored the need for effective surveillance to track HIV variants and to direct research and prevention activities"
http://www.mendeley.com/research/the-emerging-genetic-diversity-of-hiv-t
he-importance-of-global-surveillance-for-diagnostics-research-and-prevention/
Just one of many websites talking about this subject that no-one wants to talk about.
"The discovery of highly divergent strains of human immunodeficiency virus (HIV) not reliably detected by a number of commonly used diagnostic tests has underscored the need for effective surveillance to track HIV variants and to direct research and prevention activities"
http://www.mendeley.com/research/the-emerging-genetic-diversity-of-hiv-t
he-importance-of-global-surveillance-for-diagnostics-research-and-prevention/
Just one of many websites talking about this subject that no-one wants to talk about.
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