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Heart Disease (Expert Forum)
Aortic Insuf and Osteogenesis Imperfecta and a new Drug Pamidronate
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Aortic Insuf and Osteogenesis Imperfecta and a new Drug Pamidronate
by Lori Z, Jul 06, 2001 12:00AM
I am a 28 year old female who has Osteogenesis Imperfecta. I have Aortic Regirg -- Mild to Moderate. I am consisdering starting a drug called PAMIDRONATE in efforts to increase my bond densisty. I was wondering if this drug would impact my heart condition in a negative way.This drug has been around for a while and is used with cancer patients but is showing promise with OI.. Thank you for your assistance.
Doctor's Answer
by CCF-M.D.-CRC, Jul 06, 2001 12:00AM
Dear lori,
Pamidronate (pa-mi-DROE-nate) is used to treat hypercalcemia (too much calcium in the blood) that may occur with some types of cancer. It is also used to treat Paget's disease of bone and to treat bone metastases (spread of cancer).
There are no reported effects on aortic regurg. Here are some potential side-effects.
Check with your doctor as soon as possible if any of the following side effects occur:
More common
Abdominal cramps; chills; confusion; fever; muscle spasms; sore throat;
Note: Abdominal cramps, confusion, and muscle spasms are less common when pamidronate is given in doses of 60 mg or less.
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
More common
—at higher doses
Nausea; pain and swelling at place of injection.
Less common
Muscle stiffness.
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Pamidronate (pa-mi-DROE-nate) is used to treat hypercalcemia (too much calcium in the blood) that may occur with some types of cancer. It is also used to treat Paget's disease of bone and to treat bone metastases (spread of cancer).
There are no reported effects on aortic regurg. Here are some potential side-effects.
Check with your doctor as soon as possible if any of the following side effects occur:
More common
Abdominal cramps; chills; confusion; fever; muscle spasms; sore throat;
Note: Abdominal cramps, confusion, and muscle spasms are less common when pamidronate is given in doses of 60 mg or less.
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
More common
—at higher doses
Nausea; pain and swelling at place of injection.
Less common
Muscle stiffness.
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
Janelle