Heart Disease Community
Atenolol for LQT?
About This Community:

Join others with Heart Disease and get guidance and support. Ask a question, join a conversation, share experiences.

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank
Blank Blank

Atenolol for LQT?

Dear Cleveland MD:

Atenolol seemed to cause higher mortality in LQT pediatric patients in older literature.

More recently, another article points out the inferiority of Atenolol:

Abstract
Beta-blocker therapy is one of the principal therapies for congenital long-QT syndrome (LQTS). However, breakthrough cardiac events occur while being treated with beta-blockers. We sought to determine the frequency of and clinical correlates underlying beta-blocker therapy failures in genotyped, symptomatic LQTS probands. The medical records were analyzed only for genotyped LQTS probands who presented with a LQTS-attributable clinical event and were receiving beta-blocker therapy. The study cohort comprised 28 such patients: 18 KCNQ1/KVLQT1(LQT1), 7 KCNH2/HERG (LQT2), and 3 SCN5A (LQT3). The prescribed beta-blocker was atenolol (12), propranolol (10), metoprolol (4), and nadolol (2). Beta-blocker therapy failure was defined as breakthrough cardiac events including syncope, aborted cardiac arrest (ACA), appropriate implantable cardioverter-defibrillator (ICD) therapy, or sudden death occurring while on beta-blocker therapy. During a median follow-up of 46 months, 7/28 (25%) LQTS probands experienced a total of 15 breakthrough cardiac events. Their initial presentation was ACA (3), bradycardia during infancy (2), and syncope (2). The underlying genotype was KVLQT1 (6) and HERG (1). Two breakthroughs were attributed to noncompliance. Of the 13 breakthroughs occurring while compliant, 10 occurred with atenolol and 3 with propranolol (p = 0.03). In this study cohort, one-fourth of genotyped LQTS probands failed beta-blocker therapy. Treatment with atenolol, young age at diagnosis, initial presentation with ACA, KVLQT1 genotype, and noncompliance may be important factors underlying beta-blocker therapy failures.

Why is Atenolol still being used?

Thanks


This discussion is related to Long QT Syndrome.
Related Discussions
Post a Comment
To
Top Heart Disease Answerers
159619 tn?1318997813
Blank
erijon
Salt Lake City, UT
Avatar f tn
Blank
achillea
CA
11548417 tn?1440481484
Blank
Ger57
Netherlands
Avatar m tn
Blank
tacolino
Ireland
Avatar m tn
Blank
Occupant
IL
144586 tn?1284669764
Blank
caregiver222
Blank
BloodPressure Tracker
Monitor Your Blood Pressure
Start Tracking Now
Blank
HeartRhythm Tracker
Track your Heart Condition
Start Tracking Now
Recent Activity
370181 tn?1428180348
Blank
RubyWitch Life is short......ride you... Comment
5 hrs ago
1236893 tn?1408490528
Blank
408795 tn?1324939275
Blank
fretboard uploaded new photos
May 04
Heart Disease Community Resources
RSS Expert Activity
233488 tn?1310696703
Blank
Marathon Running Done Over Many Yea...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
233488 tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
748543 tn?1443740527
Blank
TMJ/TMJ The Connection Between Teet...
01/15 by Hamidreza Nassery , DMD, FICOI, FAGD, FICCMOBlank
Top Heart Disease Answerers
159619 tn?1318997813
Blank
erijon
Salt Lake City, UT
Avatar f tn
Blank
achillea
CA
11548417 tn?1440481484
Blank
Ger57
Netherlands
Avatar m tn
Blank
tacolino
Ireland
Avatar m tn
Blank
Occupant
IL
144586 tn?1284669764
Blank
caregiver222