Aa
A
A
Close
Avatar universal
Atenolol for LQT?
Dear Cleveland MD:

Atenolol seemed to cause higher mortality in LQT pediatric patients in older literature.

More recently, another article points out the inferiority of Atenolol:

Abstract
Beta-blocker therapy is one of the principal therapies for congenital long-QT syndrome (LQTS). However, breakthrough cardiac events occur while being treated with beta-blockers. We sought to determine the frequency of and clinical correlates underlying beta-blocker therapy failures in genotyped, symptomatic LQTS probands. The medical records were analyzed only for genotyped LQTS probands who presented with a LQTS-attributable clinical event and were receiving beta-blocker therapy. The study cohort comprised 28 such patients: 18 KCNQ1/KVLQT1(LQT1), 7 KCNH2/HERG (LQT2), and 3 SCN5A (LQT3). The prescribed beta-blocker was atenolol (12), propranolol (10), metoprolol (4), and nadolol (2). Beta-blocker therapy failure was defined as breakthrough cardiac events including syncope, aborted cardiac arrest (ACA), appropriate implantable cardioverter-defibrillator (ICD) therapy, or sudden death occurring while on beta-blocker therapy. During a median follow-up of 46 months, 7/28 (25%) LQTS probands experienced a total of 15 breakthrough cardiac events. Their initial presentation was ACA (3), bradycardia during infancy (2), and syncope (2). The underlying genotype was KVLQT1 (6) and HERG (1). Two breakthroughs were attributed to noncompliance. Of the 13 breakthroughs occurring while compliant, 10 occurred with atenolol and 3 with propranolol (p = 0.03). In this study cohort, one-fourth of genotyped LQTS probands failed beta-blocker therapy. Treatment with atenolol, young age at diagnosis, initial presentation with ACA, KVLQT1 genotype, and noncompliance may be important factors underlying beta-blocker therapy failures.

Why is Atenolol still being used?

Thanks


This discussion is related to Long QT Syndrome.
Cancel
0 Answers
Page 1 of 1
Your Answer
Avatar universal
Answer
Do you know how to answer? Tap here to leave your answer...
Answer
Answer
Post Answer
A
A
Top Heart Disease Answerers
159619 tn?1318997813
Blank
Salt Lake City, UT
11548417 tn?1440481484
Blank
Netherlands
144586 tn?1284669764
Blank
Avatar universal
Blank
Avatar universal
Blank
Ireland
Blank
BloodPressure Tracker
Monitor Your Blood Pressure
Start Tracking Now
Blank
HeartRhythm Tracker
Track your Heart Condition
Start Tracking Now
Recent Activity
Avatar universal
Blank
Ash1057 is ... Comment
3 hrs ago
4522800 tn?1470329434
Blank
VICourageous commented on dominosarah's status
6 hrs ago
Avatar universal
Blank
venkitvv is ... Comment
10 hrs ago
Heart Disease Community Resources