Atrial septal aneurysms typically don't rupture the same way that intracranial aneurysms do. In fact many of them have perforations and patent foramen ovale. Many of us have patent foramen ovale (about 25% of population) and clearly the stroke rate doesn't come anywhere near that number in younger patients. So having a PFO or an ASA in and of itself isn't necessarily a risk for stoke. There are other factors such as hypercoagulable state or presence of atrial arrhythmias that may have a greater role in causing strokes in general, and because PFO's are very common, it just happens that they are associated with that (not necessary a cause). Anyways, because the risk of bleeding in patients with EDS is higher than the general population I would not recommend daily ASA therapy for the prevention of stroke in this case.
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