Beta Blockers with Melfoquine

  I am on low doses of atenolol  25 mg.for mild hypertension 145/95.  I will need to take Larium (Melfoquine) for malaria prophylaxis for 8 weeks.  Are there any reports of untoward cardiac reactions when these drugs are taken together?  I had a period of PVC's lasting for 8 months at 250 PVC's per day.  One year ago I went back into normal rhythm and do not have any except for an occasional one.   Thanks for any answer..
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Dear Jim:
Atenolol and mefloquine can potentially interact.  Their concurrent use can cause abnormalities on the electrocardiogram; there are reports of cardiac arrest from simultaneous use of these drugs.  In addition, mefloquine can cause extra heart beats (PVCs), while atenolol can suppress them.  Using two or more medications simultaneously always raises the possibility of drug interactions.  The risks of possible interactions need to be weighed against the benefits of the medications.  This is something that is best done by your own doctor, who knows you and your medical history.  Do not stop taking atenolol without consulting your physician, as sudden cessation of this class of medications can cause problems.
If you wish to be evaluated here at the Cleveland Clinic, please call 1-800-CCF-CARE for an appointment with a cardiologist.  Information provided in the Heart Forum is for general purposes only.  Specific diagnoses and therapies can only be provided by your doctor.